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ProteomicsProteomic landscape of multi-layered breast cancer internal tumor heterogeneity
Breast cancer often presents with a high degree of intratumor heterogeneity, resulting in therapy resistance and tumor relapse. Here, we investigated spatial intratumor heterogeneity by integrating histopathological analyses and mass spectrometry-based proteomics. Using multilayered heterogeneity sc...
ORGANISM(S): Homo sapiens (Human) 
2025-08-10 | PXD024190 | Pride
Breast cancer Proteomics Intratumor heterogeneity Mass spectrometry 
ProteomicsAPOBEC mutagenesis and copy number alterations are drivers of proteogenomic tumor evolution and heterogeneity in metastatic thoracic tumors
Intratumor mutational heterogeneity has been documented in primary non-small cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using whole-exome and transcriptome sequencing, SNP array for cop...
ORGANISM(S): Homo sapiens (Human) 
2019-05-07 | PXD012845 | Pride
Proteomics Tumor heterogeneity rapid autopsy 
ProteomicsQuantification of Proteome heterogeneity in benign and malignant prostate tissues
Intra-tumor heterogeneity (ITH) has been studied at the morphologic, genomic, and transcriptomic level, but not proteomic level. Recent advances in mass spectrometric (MS) proteome quantification techniques, exemplified by SWATH-MS, a massively parallel targeting method, now also support precise qua...
ORGANISM(S): Homo sapiens (Human) 
2018-08-13 | PXD003497 | Pride
Intra-tumor heterogeneity  prostate cancer  pct-swath 
GenomicsExtensive three-dimensional intratumor proteomic heterogeneity revealed by multiregion sampling in high-grade serous ovarian tumor specimens
Enriched tumor epithelium, tumor-associated stroma, and whole tissue were collected by laser microdissection from thin sections across spatially separated levels of ten high-grade serous ovarian carcinomas (HGSOCs) and analyzed by mass spectrometry, reverse phase protein arrays, and RNA sequencing. ...
EGAS00001005786 | EGA
UnknownDissection of depression heterogeneity using proteomic clusters.
Not available
S-EPMC10235664 | biostudies-literature
ProteomicsNannochloropsis oceanica cultivations display phenotypic heterogeneity in lipid metabolism
By combination of FACS sorting based on lipid sensitive Nile Red staining and small cell number proteomics the occurrence of population heterogeneity was analyzed. First population heterogeneity was identified by Nile Red staining and FACS in N. oceanica cells grown in nitrogen replete and nitrogen ...
ORGANISM(S): Nannochloropsis oceanica strain IMET1 
2019-02-15 | PXD008721 | Pride
Population heterogeneity  nannochloropsis oceanica  lipid metabolism  small cell number proteomics 
ProteomicsQuantitative mass spectrometry to interrogate proteomic heterogeneity in metastatic lung adenocarcinoma and validate a novel somatic mutation CDK12-G879V
Lung cancer is the leading cause of cancer death both in men and women. Tumor heterogeneity is an impediment to targeted treatment of all cancers, including lung cancer. Here, we sought to characterize changes in tumor proteome and phosphoproteome by longitudinal, prospective collection of tumor tis...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010779 | Pride
Lung adenocarcinoma Proteomic heterogeneity Quantitative mass spectrometry 
ProteomicsSpatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma
The inter-patient variability of tumor proteomes has been investigated on a large scale but many tumors display also intra-tumoral heterogeneity (ITH) regarding morphological and genetic features. To what extent the local proteome of tumors intrinsically differs remains largely unknown. Here, we use...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-01-24 | PXD007052 | Pride
Intra-tumoral heterogeneity Liver Hepatocellular carcinoma 
UnknownOrganelle proteomic profiling reveals lysosomal heterogeneity in association with longevity.
Not available
S-EPMC10876212 | biostudies-literature
UnknownIntegrated spatial proteomic analysis of breast cancer heterogeneity unravels cancer cell phenotypic plasticity.
Not available
S-EPMC12647654 | biostudies-literature
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