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ProteomicsComplete loss of H3K9 methylation dissolves mouse heterochromatin organization
Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms. In mammalian cells, H3K9 methylation can be catalyzed by at least six distinct SET domain enzymes: Suv39h1/Suv39h2, Eset1/Eset2 and G9a/Glp. We used m...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-27 | PXD018175 | Pride
Repeat silencing Heterochromatin organization Histone methyltransferases Proteomic quantification of h3k9 methylation Genome stability 
ProteomicsLoss of H3K9 tri-methylation alters mitotic chromosome compaction and transcription factor retention during mitosis
Recent studies have shown that repressive chromatin machinery, including DNA methyltransferases (DNMTs) and Polycomb Repressor Complexes (PRCs), bind to chromosomes throughout mitosis and their depletion results in increased chromosome size. Enzymes that catalyse H3K9 methylation, such as Suv39h1, S...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-12 | PXD030771 | Pride
Chromatin  mitotic chromosomes  h3k9me3  suv39h1  suv39h2  ezh2  esrrb 
UnknownA novel proteomics approach to epigenetic profiling of circulating nucleosomes.
Not available
S-EPMC8012598 | biostudies-literature
ProteomicsDNA damage stress control is a tLT- and EHMT2-dependent central feature of Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high mortality rate. Merkel cell polyomavirus (MCPyV) is the etiology of 80% of MCC cases via expression of the viral oncogenes small T antigen (sT) and truncated large T antigen (tLT). These proteins impair the Rb1-dependent G1/S check...
ORGANISM(S): Homo sapiens (Human) 
2024-06-04 | PXD044782 | Pride
Merkel cell carcinoma  truncated lt  ehmt2  proximal interactomics  proteome analysis  dna damage repair signaling. 
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