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UnknownDiscovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development.
Not available
S-EPMC5394527 | biostudies-literature
UnknownHistone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts.
Not available
S-EPMC3674355 | biostudies-literature
UnknownDiscovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression.
Not available
S-EPMC6545112 | biostudies-literature
UnknownResident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.
Not available
S-EPMC4185233 | biostudies-literature
UnknownDiscovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.
Not available
S-EPMC7981784 | biostudies-literature
UnknownTranscellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling.
Not available
S-EPMC4419346 | biostudies-literature
UnknownDiscovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.
Not available
S-EPMC5788414 | biostudies-literature
UnknownDiscovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression.
Not available
S-EPMC8855370 | biostudies-literature
UnknownStructure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.
Not available
S-EPMC6489120 | biostudies-literature
UnknownTargeted Degradation of BET Proteins in Triple-Negative Breast Cancer.
Not available
S-EPMC5413378 | biostudies-literature
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