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UnknownTopography, clinical, and genomic correlates of 5q myeloid malignancies revisited.
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S-EPMC3341146 | biostudies-literature
TranscriptomicsAffymetrix SNP6.0 microarray data - Myelodysplastic syndromes
Mutations in the TET2 gene are frequent in myeloid disease, although their biological and prognostic significance remains unclear. We analyzed 355 patients with myelodysplastic syndromes using ‘Next-Generation’ sequencing (NGS) for TET2 aberrations; 91 of whom were also subjected to SNP6 array kary...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-23300 | biostudies-arrayexpress
TranscriptomicsInherited and somatic defects in DDX41 in myeloid neoplasms
Most cases of adult myeloid neoplasms are routinely assumed to be sporadic. Here, we describe an adult familial acute myeloid leukemia (AML) syndrome caused by germline mutations in the DEAD/H-Box helicase gene DDX41. DDX41 was also found to be affected by somatic mutations in sporadic cases of mye...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-66668 | biostudies-arrayexpress
TranscriptomicsExpression data from patients with large granular lymphocyte leukemia
Our results suggest that STAT3 can be activated independent of key oncogenic driver mutations in its SH2 domain in a subset of patients with large granular lymphocyte disorders. We examined the gene expression pattern in T-LGL leukemias compared to controls, and the impact of the presence of STAT3 m...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-39838 | biostudies-arrayexpress
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