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TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
GenomicsLarge Scale Genotyping of Psychiatric Disorders
Large Scale Genotyping of Psychiatric Disorders
PRJNA394934 | ENA
TranscriptomicsDysregulation of NRSF/REST via EHMT1 is associated with psychiatric disorders
Genetic evidence indicates disrupted epigenetic regulation as a major risk factor for psychiatric disorders, but the molecular mechanisms that drive this association are undetermined. EHMT1 is an epigenetic repressor that is causal for Kleefstra Syndrome (KS), a neurodevelopmental disorder (NDD) lea...
ORGANISM(S): Homo sapiens 
2023-05-01 | E-MTAB-10480 | biostudies-arrayexpress
GenomicsWES of adult intellectual disabilities with co morbid psychiatric disorders
ost adults with intellectual disabilities (ID) do not undergo genetic diagnostic investigation as part of their clinical care and have 'missed the boat' with regard to the WES and WGS genetic testing that is now being provided for children with ID. There is a dramatically increased risk of psychistr...
EGAS00001002962 | EGA
TranscriptomicsTranscriptomic signatures of risk genes implicated in psychiatric disorders during neuronal differentiation
Susceptibility genes for Autism Spectrum Disorder (ASD), Fragile X Syndrome (FXS), monogenetic disorders with intellectual disabilities (ID) or schizophrenia (SCZ) converge on processes related to neuronal function and differentiation. Furthermore, ASD risk genes are enriched for FMRP (Fragile X Men...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-69838 | biostudies-arrayexpress
GenomicsUncovering altered neural molecular mechanisms in metabolic disorders induced psychiatric disorders
Uncovering altered neural molecular mechanisms in metabolic disorders induced psychiatric disorders
PRJNA1139747 | ENA
TranscriptomicsExpression data from human brain anterior cingulate cortex - including control samples and samples with major depression disorders (26 samples BA25_F)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54571 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain anterior cingulate cortex - including control samples and samples with major depression disorders (24 samples BA25_M)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54572 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain amygdala - including control samples and samples with major depression disorders (42 samples MD3_AMY)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54564 | biostudies-arrayexpress
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