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GenomicsNatural genetic variation perturbs collaborative transcription factor binding required for enhancer selection and function
Natural genetic variation between two mouse strains was used as a natural mutagenesis screen to test various aspects of the proposed model for enhancer selection and function. Chromatin marks H3K4me2, H3K27Ac, and transcription factors PU.1, C/EBPa, and p65 were assessed by ChIP-Seq and GRO-Seq and ...
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-46494 | biostudies-arrayexpress
GenomicsSPIB and BATF provide alternate determinants of IRF4 occupancy in Diffuse Large B-cell Lymphoma linked to disease heterogeneity
ChIP-seq data for the transcription factors (TFs) IRF4, PU.1 and SPIB from the cell lines OCI-LY3, OCI-LY10 and H929, and BATF from the cell lines OCI-Ly3 and OCI-Ly10. In addition ChIP-seq for the TFs IRF4, PU.1 and SPIB from the cell line OCI-LY3 following transfections of scramble/SPIB-siRNA. ChI...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-56857 | biostudies-arrayexpress
UnknownANP32B suppresses B-cell acute lymphoblastic leukemia through activation of PU.1 in mice.
Not available
S-EPMC10323103 | biostudies-literature
GenomicsIdentification and Characterization of Hoxa9 Binding Sites in Hematopoietic Cells
The clustered homeobox proteins play crucial roles in development, hematopoiesis and leukemia yet the targets they regulate and their mechanisms of action are poorly understood. Here, we identified the binding sites for Hoxa9 and the Hox cofactor Meis1 on a genome-wide level and profiled their asso...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-33509 | biostudies-arrayexpress
UnknownHypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis.
Not available
S-EPMC2964978 | biostudies-literature
UnknownTissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature.
Not available
S-EPMC5393447 | biostudies-literature
GenomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40235 | biostudies-arrayexpress
UnknownProstate cancer in Asia: design of a patient registry to inform real-world treatments, outcomes, and quality of life.
Not available
S-EPMC6713796 | biostudies-literature
UnknownUnited in Fight against prOstate cancer (UFO) registry: first results from a large, multi-centre, prospective, longitudinal cohort study of advanced prostate cancer in Asia.
Not available
S-EPMC7187217 | biostudies-literature
UnknownPan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with prostate cancer.
Not available
S-EPMC9434138 | biostudies-literature
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