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MetabolomicsIntestinal Bacillus sp. derived IBA activates PPARγ to promote PUFA synthesis in fish

Background: Marine fish are paradoxically rich in polyunsaturated fatty acids (PUFAs) despite their limited endogenous biosynthesis capacity, suggesting a critical role of exogenous acquisition or microbial contributions.

Results: Here, we characterized the gut microbiota of Seriola dumeri...

2026-02-09 | MTBLS13872 | MetaboLights
MetabolomicsHigh PUFA diet in humans
Not available
ORGANISM(S): Homo sapiens 
ST000041 | MetabolomicsWorkbench
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA or Rosiglitazone in Dietary-Obese Mice
Impaired resistance to insulin, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. The hampered metabolic adaptability triggers a further damage of insulin signaling. Since skeletal muscle is the mai...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36716 | biostudies-arrayexpress
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by a Combination Treatment using n-3 PUFA and Rosiglitazone in Dietary-Obese Mice
Impaired resistance to insulin, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. The hampered metabolic adaptability triggers a further damage of insulin signaling. Since skeletal muscle is the mai...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36717 | biostudies-arrayexpress
MetabolomicsEssential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Omega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n...

2020-11-03 | MTBLS1952 | MetaboLights
TranscriptomicsThe consequences of n-3 polyunsaturated fatty acids (PUFA) depletion on hepatic lipid metabolism in mice
In the present study, we investigated the consequences of n-3 polyunsaturated fatty acids (PUFA) depletion on hepatic lipid metabolism in mice fed during three months with a diet presenting a high n-6/n-3 PUFA ratio to induce n-3 PUFA depletion. Microarray analyses were performed to identify the mol...
ORGANISM(S): Mus musculus 
2011-08-25 | E-GEOD-26986 | biostudies-arrayexpress
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA, Rosiglitazone, and a combination of both
This SuperSeries is composed of the following subset Series: GSE36716: Muscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA or Rosiglitazone in Dietary-Obese Mice GSE36717: Muscle Involvement in Preservation of Metabolic Flexibility by a Combination Treatment using...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36718 | biostudies-arrayexpress
Transcriptomicsthe influence of a modification of the gut microbiota composition on the hepatic steatosis induced by n-3 polyunsaturated fatty acid (PUFA) depletion
in the present study, we evaluated whether microbiota modulation is able to restore hepatic steatosis induced by n-3 PUFA depletion in mice. For this purpose, mice were fed during three months with a n-3 PUFA-depleted diet (presenting a high n-6/n-3 PUFA ratio), and then supplemented with fructoolig...
ORGANISM(S): Mus musculus 
2012-12-12 | E-GEOD-31727 | biostudies-arrayexpress
TranscriptomicsscAT gene expression from women with PCOS following LC n-3 PUFA or placebo supplementation
Gene expresion profiles from the scAT following 6 week LC n-3 PUFA and 6 week placebo supplementation were compared Women with PCOS were supplemented with 4g n-3 PUFA (containing 1.8g EPA and DHA) daily for 6 weeks and changes in subcutaneous adipose tissue gene expression was compared with 6 week p...
ORGANISM(S): Homo sapiens 
2014-01-03 | E-GEOD-43266 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Atlantic salmon liver from fish exhibiting high and low flesh n-3LC-PUFA levels at harvest
N-3 long chain polyunsaturated fatty acids (n-3LC-PUFA) are essential components of vertebrate membrane lipids and are now at critically low levels in modern Western diets. The main human dietary source for n-3LC-PUFA is fish and seafood, and over 50% of global fish production is currently supplied ...
ORGANISM(S): Salmo salar 
2010-05-01 | E-TABM-955 | biostudies-arrayexpress
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