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TranscriptomicsSorted B cells from mice treated with MPL and/or R837
Many successful vaccines induce persistent antibody responses that can last a lifetime. The mechanisms by which they do so remain unclear, but emerging evidence suggests that activate dendritic cells (DCs) via Toll-like receptors (TLRs). For example, the yellow fever vaccine YF-17D, one of the most...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-25677 | biostudies-arrayexpress
TranscriptomicsMicroarray analyses of lymph node dendritic cells (DCs) stimulated in vitro with papain or LPS
T helper type 2 (Th2) responses are induced by protease allergens and helminthes. However the molecular mechanisms that initiate Th2 responses are poorly understood. To obtain insight into this mechanism, we performed a microarray analysis of lymph node DCs stimulated in vitro with the protease alle...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-21602 | biostudies-arrayexpress
TranscriptomicsFACS-sorted cells from Young Adults Vaccinated with Influenza TIV or LAIV Vaccines during 2008/09 Flu Season
Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying the innate responses to the trivalent inactivat...
ORGANISM(S): Homo sapiens 
2011-07-10 | E-GEOD-29618 | biostudies-arrayexpress
GenomicsThe effects of SCAP deletion on gene expression of activated B cells
The effects of SCAP deletion on gene expression of activated B cells
PRJNA842708 | ENA
GenomicsSREBP signaling is essential for effective B cell responses and memory formation
SREBP signaling is essential for effective B cell responses and memory formation
PRJNA848798 | ENA
GenomicsMus musculus
Sorted B cells from mice treated with MPL and/or R837
PRJNA133875 | ENA
TranscriptomicsTLR-mediated type I IFN induction in pDCs requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway
Robust type I interferon (IFN-alpha/beta) production in plasmacytoid dendritic cells (pDCs) is critical for anti-viral immunity. Here we demonstrated a role for the mammalian target of rapamycin (mTOR) pathway in regulating interferon production by pDCs. Inhibition of mTOR or the ‘downstream’ mediat...
ORGANISM(S): Mus musculus 
2008-12-01 | E-GEOD-12218 | biostudies-arrayexpress
MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
TranscriptomicsSystems biological analysis of immunity to dengue
Dengue virus (DENV) infects hundreds of millions of people annually, yet there is only a limited knowledge of the host immune response to dengue. Here, we used a systems biological approach to perform a detailed analysis of the innate immune response to DENV infection in the whole blood samples of a...
ORGANISM(S): Homo sapiens 
2014-06-27 | E-GEOD-51808 | biostudies-arrayexpress
TranscriptomicsTime Course of Young Adults Vaccinated with Influenza TIV Vaccine during 2007/08 Flu Season
Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying the innate responses to the trivalent inactivat...
ORGANISM(S): Homo sapiens 
2011-07-10 | E-GEOD-29614 | biostudies-arrayexpress
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