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TranscriptomicsTranscription profiling of normoxic and hypoxic mice to elucidate the genes involved in vascular remodeling following pulmonary hypertension
Hypoxia can induce vasoconstriction followed by vascular remodeling including hypertrophy and hyperplasia of pulmonary vascular smooth muscle and proliferation of endothelial cells. The goal of this project is to elucidate the genes involved in vascular remodeling following pulmonary hypertension. ...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-482 | biostudies-arrayexpress
ProteomicsPhysiological shear stress markedly alters the proteomic response to hypoxia in human pulmonary microvascular endothelial cells
Physiological shear stress, produced by blood flow, homeostatically regulates the phenotype of pulmonary endothelial cells exerting anti-inflammatory and anti-thrombotic actions and maintaining normal barrier function. In the pulmonary circulation hypoxia, due to high altitude or diseases such as CO...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD036260 | Pride
Shear stress Copd Human pulmonary microvascular endothelial cells Hypoxia 
TranscriptomicsEndothelial DNA methalytion signature in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a severe and incurable pulmonary vascular disease. One of the primary origins of PAH is pulmonary endothelial dysfunction leading to vasoconstriction, aberrant angiogenesis and smooth muscle cell proliferation, endothelial-to-mesenchymal transition, thrombosi...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-84395 | biostudies-arrayexpress
UnknownInhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice.
Not available
S-EPMC7745575 | biostudies-literature
UnknownMitochondrial transplantation attenuates hypoxic pulmonary vasoconstriction.
Not available
S-EPMC5058756 | biostudies-literature
UnknownAcute vasoreactivity testing during right heart catheterization in chronic thromboembolic pulmonary hypertension: Results from the pulmonary vascular disease phenomics study.
Not available
S-EPMC9817070 | biostudies-literature
UnknownEndocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction.
Not available
S-EPMC3831960 | biostudies-literature
UnknownCytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.
Not available
S-EPMC1993904 | biostudies-literature
UnknownAltered Lipid Domains Facilitate Enhanced Pulmonary Vasoconstriction after Chronic Hypoxia.
Not available
S-EPMC7258824 | biostudies-literature
ProteomicsEffect of mitochEffect of mitochondrial complex III chronic inhibition on mitochondrial proteomic landscapeondrial complex III chronic inhibition on mitochondrial proteomic landscape
The mitochondria play a vital role in controlling cell metabolism and regulating crucial cellular outcomes. We previously demonstrated that chronic inhibition of the mitochondrial complex III in rats by Antimycin A (AA) induced pulmonary vasoconstriction. On the metabolic level, AA-induced mitochond...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD020551 | Pride
Antimycin a Pulmonary vasoconstriction Mitochodria Quantitative proteomics 
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