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TranscriptomicsChromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent.
Background & Aims: The metastatic process is complex and remains a major obstacle in the management of colorectal cancer (CRC). To gain a better insight into the biologic events driving the metastatic process we investigated genomic aberrations in a large cohort of matched CRC primaries and distant ...
ORGANISM(S): Homo sapiens 
2014-02-10 | E-GEOD-38479 | biostudies-arrayexpress
UnknownBody Mass Index Is Prognostic in Metastatic Colorectal Cancer: Pooled Analysis of Patients From First-Line Clinical Trials in the ARCAD Database.

Purpose

In recent retrospective analyses of early-stage colorectal cancer (CRC), low and high body mass index (BMI) scores were associated with worsened outcomes. Whether BMI is a prognostic or predictive factor in metastatic CRC (mCRC) is unclear.

Patients and methods

Individual data...
S-EPMC5070548 | biostudies-literature
UnknownPhase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma.

Purpose

In phase I/II trials, the cytotoxic T lymphocyte-associated antigen-4-blocking monoclonal antibody tremelimumab induced durable responses in a subset of patients with advanced melanoma. This phase III study evaluated overall survival (OS) and other safety and efficacy end points in p...
S-EPMC4878048 | biostudies-literature
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