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UnknownThe chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.
Not available
S-EPMC2643500 | biostudies-literature
UnknownDiverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p.
Not available
S-EPMC126167 | biostudies-literature
UnknownA crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors.
Not available
S-EPMC2768557 | biostudies-literature
UnknownRecognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.
Not available
S-EPMC3003032 | biostudies-literature
ProteomicsPhosphosecretome profiling and kinase-substrate interaction screening reveal key extracellular c-Src-regulated pathways
Secreted protein kinases are responsible for the phosphorylation of a vast number of extracellular phosphoproteins. The tyrosine kinase c-Src is secreted through the vesicular trafficking pathway, however, mechanistic insights into extracellular substrate specificity and potential therapeutic opport...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-05-30 | PXD036069 | Pride
Post translational modification The tissue inhibitors of metalloproteinases Pxxp motif Src tyrosine kinase Timps Tumor growth inhibition Phosphoproteomic Blocking antibodies Secretome 
UnknownModulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif.
Not available
S-EPMC11024197 | biostudies-literature
UnknownReplacement of the hepatitis E virus ORF3 protein PxxP motif with heterologous late domain motifs affects virus release via interaction with TSG101.
Not available
S-EPMC4679584 | biostudies-literature
UnknownSH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55.
Not available
S-EPMC203341 | biostudies-literature
UnknownA Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.
Not available
S-EPMC4689412 | biostudies-literature
UnknownCrystal Structure of the SH3 Domain of ASAP1 in Complex with the Proline Rich Motif (PRM) of MICAL1 Reveals a Unique SH3/PRM Interaction Mode.
Not available
S-EPMC9865144 | biostudies-literature
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