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MetabolomicsMetabolomic approaches to dissect dysregulated metabolism in the progression of pre-diabetes to T2DM

Most of pre-diabetes were eventually progress to diabetes, thereby profiling of prediabetic metabolic disorders may be an effective targeted preventive measure. We aimed to elucidate internal motivation of the progression of pre-diabetes to type 2 diabetes mellitus (T2DM) from a metabolic perspec...

2024-04-29 | MTBLS8644 | MetaboLights
ProteomicsAnalysis of protein expression changes in patients with prediabetes using high-throughput proteomics
Objective: This study aimed to explore the mechanisms of early-onset T2DM by analyzing proteomic changes at different stages of glucose metabolism. Methods: A total of 40 individuals undergoing routine physical health examinations between December 2016 and April 2017 were enrolled. Subjects were di...
ORGANISM(S): Homo Sapiens 
PXD035367 |
ProteomicsMechanistic view of NMNAT chaperoning different pathological proteins against amyloid aggregation
The cross-linking mass spectrometry raw data of NMNAT and amyloid client proteins including α-syn, K19, Aβ40, and IAPP.
ORGANISM(S): Homo Sapiens 
2022-02-11 | PXD031653 |
ProteomicsIL-17A and TNF-α inhibitors induce multiple molecules andsignal pathway change in psoriasis
Adalimumab and secukinumab are commonly used for moderate-severe psoriasis vulgaris (PV), but distinct individual response and impaired effectiveness happen occasionally. Little is known about it. Here, we report a proteomic analysis of psoriatic lesions from patients treated with these drugs using ...
ORGANISM(S): Homo Sapiens 
2022-10-20 | PXD037579 |
ProteomicsPRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub
A major challenge to the current efforts to cure HIV-1 infection is the persistence of latent viruses. Addressing this challenge hinges on unraveling the intricate interplay between the host and viral factors that are key for HIV-1 latency. Current antiretroviral agents effectively prevent actively ...
ORGANISM(S): Homo Sapiens 
2025-03-25 | PXD062187 |
TranscriptomicsContribution of WDR77 and p53 to androgen response in prostate cancer cells
To decipher the contribution of WDR77 and p53 to androgen-responsive gene expression, effect of siRNA-mediated silencing of WDR77 and p53 on expression of androgen-dependent genes was studied. Human LNCaP prostate cancer cells were transfected with individual siRNA SmartPools targeting WDR77 or p53 ...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-66977 | biostudies-arrayexpress
ProteomicsArbuscular mycorrhizal plant salt stressA
a label-free quantitative proteomics method was employed to identify the differentially abundant proteins in AM E. angustifolia seedlings under salt stress.
ORGANISM(S): Elaeagnus Angustifolia 
2022-12-18 | PXD038883 |
UnknownThe influence of genetic variants of sorafenib on clinical outcomes and toxic effects in patients with advanced renal cell carcinoma.
Not available
S-EPMC4735712 | biostudies-literature
TranscriptomicsEvaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer
We evaluated the genome-wide microRNA expression profiles in lymphoblastoid cell lines of familial ovarian cancer patients and controls We used microarray to perform microRNA profiling in lymphoblastoid cell lines from 74 women with familial ovarian cancer patients and 47 controls.
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-31801 | biostudies-arrayexpress
ProteomicsN-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine
To characterize the accessibility of α-syn to LPC and DOPS, we performed cross-linking experiments coupled with mass spectrometry (XL-MS). We mixed 15N-labeled and unlabeled Ac-α-syn at a 1:1 ratio and selected the cross-linked fragments containing both 15N-labeled and unlabeled Ac-α-syn to map the ...
ORGANISM(S): Homo Sapiens 
2024-12-26 | PXD059259 |
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