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TranscriptomicsInterplay between AP-1 and ERalpha in regulating gene expression and proliferation networks in breast cancer cells
Estrogen receptor alpha (ERalpha) is a ligand-dependent transcription factor that plays an important role in breast cancer. Estrogen-dependent gene regulation by ERalpha can be mediated by interaction with other DNA-binding proteins, such as activator protein-1 (AP-1). The nature of such interaction...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36586 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of inflammatory cistrome reveals AP-1/c-Jun as a key regulator of TNFalpha-mediated triple-negative breast cancer progression [microarray]
Triple-negative breast cancer (TNBC) represents a highly aggressive form of breast cancer with limited treatment options. Proinflammatory cytokines such as TNFalpha can facilitate tumor progression and metastasis. However, our knowledge of the molecular mechanisms underlying TNBC progression mediate...
ORGANISM(S): Homo sapiens 
2016-01-20 | E-GEOD-71915 | biostudies-arrayexpress
TranscriptomicsInsights into the invasiveness of triple negative breast cancer from genome-wide profiling of transcription factor AP-1 (expression)
Triple negative breast cancer (TNBC) is an aggressive clinical phenotype, and accounts for 15% to 20% of all breast cancers. The molecular determinants of malignant cell behaviors in TNBC remain largely unknown. We find that the AP-1 transcription factor component, Fra-1, is overexpressed in basal-l...
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-46440 | biostudies-arrayexpress
UnknownInsights into the invasiveness of triple negative breast cancer from genome-wide profiling of transcription factor AP-1 (expression)
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-46440 | biostudies-other
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