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Proteomics3D Mechanical Stimulation Modulates Endothelial Exosomes to Promote Fibroblast Activation
Background: Mechanical forces play a crucial role in regulating cellular communication during tissue repair, yet how mechanical stimulation modulates endothelial exosome secretion and their effects on fibroblast activation remains unclear. Methods: In this study, endothelial cells were incorporated ...
ORGANISM(S): Homo Sapiens 
2025-12-25 | PXD072415 |
ProteomicsO-GlcNAcylation of RPA2 at S4/S8 antagonizes phosphorylation and regulates checkpoint activation during replication stress
O-linked N-acetylglucosamine (O-GlcNAc) is the only mono-saccharide modification occurring in the cytoplasm, nucleus and mitochondria. Recent advent of the mass spectrometry technology has enabled identification of abundant O-GlcNAc transferase (OGT) substrates in diverse biological processes, such ...
ORGANISM(S): Homo Sapiens 
2024-06-21 | PXD053321 |
ProteomicsO-GlcNAcase SUMOylation studies identify the SUMO-code in chaperone-mediated autophagy
O-GlcNAcase (OGA) is the sole eraser for the intracellular O-linked N-acetylglucosamine (O-GlcNAc). OGA has many roles in diverse processes, such as cancer and embryonic stem cells, but its exact regulating mechanism is far from understood. Herein we studied small ubiquitin-like modifier (SUMO) modi...
ORGANISM(S): Homo Sapiens 
2024-10-13 | PXD056772 |
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