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ProteomicsXIAMENUNIVERSITY-QIUYAN-Eucalyptal A (ykz1316)
Eucalyptal A, an organic heterotetracyclic compound from Eucalyptus globulus ( 468.29 g/mol), possesses antineoplastic activity, serving as a metabolite and potential antineoplastic agent with diverse structural affiliations.
ORGANISM(S): Eucalyptus Globulus (ncbitaxon:34317) 
2025-10-27 | MSV000099613 | MassIVE
TranscriptomicsTranscription profiling of human cell cancer line treated with bortezomib or Eeyarestatin I (EerI) reveals ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3 only protein NOXA in cancer cells
The ubiquitin-proteasome system (UPS) has recently emerged as a major target for drug development in cancer therapy. The proteasome inhibitor bortezomib has clinical activity in multiple myeloma and mantle cell lymphoma. Here we report that Eeyarestatin I (EerI), a chemical inhibitor that blocks ER-...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-14003 | biostudies-arrayexpress
TranscriptomicsThe ERAD inhibitor Eeyarestatin I is a bifunctional compound with an ER localizing domain and a p97/VCP inhibitory group
Protein homeostasis in the endoplasmic reticulum (ER) has recently emerged as a therapeutic target for cancer treatment. Disruption of ER homeostasis results in ER stress, which is a major cause of cell death for cells exposed to the proteasome inhibitor Bortezomib, an anti-cancer drug approved for ...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-23849 | biostudies-arrayexpress
TranscriptomicsCarboxypeptidase of glutamate-like gene as a tumor suppressor in pancreatic cancer cells and a prognostic marker for resected pancreatic cancer patients
Pancreatic cancer is the fourth leading cancer-related death in United States. The clinical relevance of genomic imbalances in pancreatic cancer is uncertain. We performed array-comparative genomic hybridization (aCGH) in 44 resected pancreatic cancer specimens from a Korean cohort. We observed recu...
ORGANISM(S): Homo sapiens 
2011-04-21 | E-GEOD-28732 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse xenograft L2987 lung tumor tissue samples
Transcriptional profiling was conducted on RNA from 8 xenograft L2987lung tumor tissue samples to identify genes affected by treatment with a VEGFR-2 small molecule inhibitor Experiment Overall Design: Baseline and 14 days post treatement gene expression profiling was performed using 8 xenograft L29...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7209 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon tumor tissue samples to identify genes whose expression level correlates with VEGFR-2 expression
Transcriptional profiling was conducted on RNA from 59 human colon tumor tissue samples to identify genes whose expression level correlates VEGFR-2 Experiment Overall Design: Baseline gene expression profiling was performed using 59 human colon tumor tissue samples to identify genomic signatures hig...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7208 | biostudies-arrayexpress
ProteomicsNMT2 alleviated the depression-like behavior：integrated proteomic and phosphoproteomic analysis of chronic unpredictable stress in rats
Proteomics has been widely used to investigate multiple diseases, and combining proteomics with phosphoproteomics analysis would further explain the pathological mechanisms of depression. The study induced depression-like behavior in rats using CUMS and conducted sucrose preference test, open field ...
ORGANISM(S): Rattus Rattus 
2024-03-18 | PXD050750 |
TranscriptomicsInterferon gamma down-regulates miR-3473b to promote macrophage activation
Macrophages are major effector cells and antigen presenting cells of the innate immune system and classical activation of macrophage function requires interferon–γ (IFN-γ) pretreatment (priming) and TLR stimuli, which promotes inflammatory responses though high levels of pro-inflammatory cytokines a...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-50569 | biostudies-arrayexpress
GenomicNCI Lung Cancer and Smoking Phenotypes in African-American Subjects

This is a two-stage case-control study designed to evaluate the association between common genetic variants and the risk of lung cancer. The stage 1 studies included 1737 cases and 3602 controls from the following studies: MD Anderson Lung Cancer Epidemiology Study, The Multiethnic Cohort Study (...

phs001210 | dbGaP
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