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UnknownMETTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner.
Not available
S-EPMC9284900 | biostudies-literature
UnknownA multi-omics approach identifies the key role of disorders of sphingolipid metabolism in Ang II-induced hypertensive cardiomyopathy myocardial remodeling.
Not available
S-EPMC11621778 | biostudies-literature
UnknownHDL attenuates Ang II–AT1R–EGFR signaling and reverses vascular remodeling in spontaneously hypertensive rats
Not available
S-EPMC12339555 | biostudies-literature
ProteomicsCardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling
Hypertensive heart failure highlights an urgent need for effective therapeutic strategies. Protein kinases regulate multiple pathways in cardiac pathophysiology and may provide promising therapeutic targets. Here, we identified a Cyclin-dependent kinase, CDK9, promoting inflammation and cardiac remo...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-15 | PXD074483 | Pride
Angiotensin ii  cdk9  nf-κb p65  cardiac remodeling  cardiomyocytes 
ProteomicsCardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling
Hypertensive heart failure highlights an urgent need for effective therapeutic strategies. Protein kinases regulate multiple pathways in cardiac pathophysiology and may provide promising therapeutic targets. Here, we identified a Cyclin-dependent kinase, CDK9, promoting inflammation and cardiac remo...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD074496 | Pride
Angiotensin ii  cdk9  nf-κb p65  cardiac remodeling  cardiomyocytes 
UnknownBlood-brain barrier-penetrating Angiopep-2/Sirtuin 1 nanoparticles rescue sevoflurane neurotoxicity through multi-omics identified necroptosis pathways.
Not available
S-EPMC12369234 | biostudies-literature
UnknownEnhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole.
Not available
S-EPMC5668650 | biostudies-literature
UnknownFucoidan inhibits apoptosis and improves cardiac remodeling by inhibiting p53 transcriptional activation through USP22/Sirt 1.
Not available
S-EPMC10261984 | biostudies-literature
UnknownCXCL1-CXCR2 signalling mediates hypertensive retinopathy by inducing macrophage infiltration.
Not available
S-EPMC9418605 | biostudies-literature
UnknownInhibition of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation Reduces Angiotensin II-Induced Abdominal Aortic Aneurysm Rupture in Mice.
Not available
S-EPMC8360833 | biostudies-literature
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