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UnknownPhosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study.
Not available
S-EPMC5920739 | biostudies-literature
Genomicsena-DATASET-MGH-10-02-2015-15:17:58:985-1 - samples
DNA was derived from the primary tumour, lung metastasis, and peri-aortic lymph node metastasis. DNA from the spleen was used as a normal control. For WE sequencing we user Hybrid capture (Nimblegen version 3.0) of the lymph node and lung metastases, primary tumour and spleen normal; we generated ~1...
EGAD00001001252 | EGA
Genomicsena-DATASET-MGH-10-02-2015-15:19:45:352-2 - samples
DNA was derived from the primary tumour, lung metastasis, and peri-aortic lymph node metastasis. DNA from the spleen was used as a normal control. WG sequencing produced ~30-fold (primary tumour, spleen normal)-50-fold (lung metastasis) coverage
EGAD00001001253 | EGA
GenomicsTherapeutic Resistance to PI3K-alpha Inhibitors
We have studied the tumor genomic evolution in a patient with metastatic breast cancer bearing an activating PIK3CA mutation. The patient was treated with the PI3Kα inhibitor BYL719 and achieved a lasting clinical response on BYL719, but eventually progressed to treatment and died shortly thereafter...
EGAS00001000991 | EGA
GenomicsMemorial Sloan Kettering Cancer Center - Human Oncology & Pathogenesis Program (HOOP) - Data Access Committee
Data Access Committee EGAC00001000305
EGAC00001000305 | EGA
Transcriptomics8 NSCLC cell lines treated with either 50nM or 100nM of AUY for 24 hours.
RNA from treated cell lines are compared to RNA from matched untreated samples on the same chip to assess differential gene expression. RNA from treated cell lines are compared to RNA from matched untreated samples on the same chip to assess differential gene expression.
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-43568 | biostudies-arrayexpress
TranscriptomicsBaseline NSCLC cell lines compared to a reference mix consisting of 45 NSCLC cell lines
34 NSCLC cell lines were transcriptionally profiled against a reference mix of 45 NSCLC cell lines to look subtype specific differential gene expression 34 individual cell lines were compared to a reference mix consiting of 45 NSCLC cell lines
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-43567 | biostudies-arrayexpress
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