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MetabolomicsProteomic analysis validates previous findings on wounding-responsive plant hormone signaling and primary metabolism contributing to the biosynthesis of secondary metabolites based on metabolomic analysis in harvested broccoli (Brassica oleracea L. var. italica)
The plant wound-response is a complex process that generates physiological modifications for protecting the wounded tissue. In this study, tandem mass tag (TMT)-based quantitative proteomic analysis was performed to clarify the comprehensive molecular mechanism for the wound-response of broccoli subj...
2021-05-19 | MTBLS2317 | MetaboLights
MetabolomicsSequential lipidomic, metabolomic, and proteomic analyses of serum, liver, and heart tissue specimens from peroxisomal biogenesis factor 11α knockout mice
Peroxisomes are versatile single membrane-enclosed cytoplasmic organelles, involved in reactive oxygen species (ROS) and lipid metabolism and diverse other metabolic processes. Peroxisomal disorders result from mutations in Pex genes-encoded proteins named peroxins (PEX proteins) and single peroxiso...
2022-02-02 | MTBLS1887 | MetaboLights
TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
MetabolomicsIntegrated Proteomic and Metabolomic Analyses Show Differential Effects of Glucose Availability in Marine Synechococcus and Prochlorococcus

We compared changes induced by the addition of 100 nM and 5 mM glucose on the proteome and metabolome complements in Synechococcus sp. strains WH8102, WH7803, and BL107 and Prochlorococcus sp. strains MED4, SS120, and MIT9313, grown either under standard light conditions or in d...

2023-02-06 | MTBLS5462 | MetaboLights
MetabolomicsCE-MS Metabolomic and LC-MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
GenomicsProteomic analysis of native hepatocyte nuclear factor-4{alpha} (HNF4{alpha}) isoforms, phosphorylation status, and interactive cofactors.
Hepatocyte nuclear factor-4α (HNF4α, NR2A1) is a nuclear receptor which has a critical role in hepatocyte differentiation and the maintenance of homeostasis in the adult liver. However, a detailed understanding of native HNF4α in the steady state remains to be elucidated. Here we report the native H...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-18990 | biostudies-arrayexpress
Metabolomicsmetabolomics Analysis in Cecal Samples
Targeted LC/MS Metabolomics. Cecal contents were lyophilized overnight and approximately 2.5-5 mg was homogenized in 250 µL of 50% acidified acetonitrile (0.3% formic acid) for targeted LC/MS/MS metabolomics (acylcarnitines, amino acids, organic acids, nucleotides, and CoAs) according to validated, ...
2026-06-19 | MTBLS14783 | MetaboLights
OtherICAT quantitative proteomic analysis of Myc-induced apoptosis
Quantitative proteomic analysis of Myc-induced apoptosis in serum-deprived Rat1_Myc fibroblasts. Mitochondrial, chromatin, and soluble fractions analyzed. Original peptide data contained in Supplementary files. Keywords: proteomic, apoptosis, cell fractions
ORGANISM(S): Rattus norvegicus 
2005-12-20 | GSE3159 | GEO
MetabolomicsMaHPIC Experiment E03 - Quantitative Metabolomics of Macaca mulatta infected with Plasmodium coatneyi Hackeri strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute, recrudescent, and chronic infections
MaHPIC Experimental Description:
Malaria-naive male rhesus macaques (Macaca mulatta), approximately four years of age, were inoculated intravenously with salivary gland sporozoites produced and isolated at the Centers for Disease Control and Prevention from multiple Anopheles
2018-09-05 | MTBLS691 | MetaboLights
MetabolomicsMaHPIC Experiment 06: Quantitative Metabolomics from Macaca mulatta infected with Plasmodium knowlesi sporozoites to produce and integrate clinical, hematological, parasitological, omics, telemetric and histopathological measures of acute primary infection
Telemetry devices (DSI, model L11) with blood pressure sensors and electrocardiogram (ECG) leads were surgically implanted in four malaria-naive male rhesus macaques (Macaca mulatta), approximately five years of age. After a resting period of two weeks, physiological data that include activit...
2019-01-14 | MTBLS824 | MetaboLights
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