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ProteomicsCo-dependent macrocyclic peptide interactions facilitate ipglycermide high affinity binding to phosphoglycerate mutases
The phylogenetic divergence between parasitic and mammalian phosphoglycerate mutases (PGMs) offers an opportunity for selective pharmacologic targeting of glycolysis in disease-causing organisms. With this aim we previously described ipglycermides, discovered by affinity selection from a vast nuclei...
ORGANISM(S): Brugia malayi Dirofilaria immitis Escherichia coli Onchocerca volvulus Caenorhabditis elegans 
2021-04-06 | PXD024074 | Pride
Phosphoglycerate mutase Proteomics Cyclic peptide Structure Interaction 
UnknownqHTSWaterfall: 3-dimensional visualization software for quantitative high-throughput screening (qHTS) data.
Not available
S-EPMC10064508 | biostudies-literature
UnknownAnnotation Query (AnnoQ): an integrated and interactive platform for large-scale genetic variant annotation.
Not available
S-EPMC9252745 | biostudies-literature
UnknownOld Polyanionic Drug Suramin Suppresses Detrimental Cytotoxicity of the Host Defense Peptide LL-37.
Not available
S-EPMC7887748 | biostudies-literature
ProteomicsPharmacoproteomic profiling directed by C. elegans-driven phenotypic quantitative HTS
Quantitative high-throughput screening (qHTS) pharmacologically evaluates libraries of drugs and investigational agents for potential therapeutic uses, toxicological risk assessment, and increasingly for academic chemical tool discovery. Phenotypic HTS assays aim to interrogate molecular pathways a...
ORGANISM(S): Caenorhabditis elegans 
2023-02-21 | PXD033552 | Pride
Model organisms Laser cytometry Proteomics Drug discovery Infectious disease Genetic disorders High-throughput screening 
UnknownIn vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Not available
S-EPMC10067442 | biostudies-literature
UnknownInterplay between membrane active host defense peptides and heme modulates their assemblies and in vitro activity.
Not available
S-EPMC8443738 | biostudies-literature
UnknownIntegrated analysis of the molecular pathogenesis of FDXR-associated disease.
Not available
S-EPMC7272433 | biostudies-literature
UnknownSerum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases.
Not available
S-EPMC9900472 | biostudies-literature
UnknownGenome-Edited Coincidence and PMP22-HiBiT Fusion Reporter Cell Lines Enable an Artifact-Suppressive Quantitative High-Throughput Screening Strategy for <i>PMP22</i> Gene-Dosage Disorder Drug Discovery.
Not available
S-EPMC8369676 | biostudies-literature
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