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MetabolomicsMechanisms of exogenous quercetin in enhancing soybean salt tolerance through regulating ion homeostasis, phytohormone signaling, and flavonoid metabolism

Increasing soil salinization poses a severe threat to global agricultural production. Quercetin, a natural compound known to effectively alleviate abiotic stress, has an unclear molecular regulatory mechanism in enhancing soybean salt tolerance. To investigate its mechanism of action, this study ...

2025-10-22 | MTBLS13197 | MetaboLights
MetabolomicsIntegrated transcriptomic and metabolomic analyses reveal the mechanism by which quercetin inhibits reflux esophagitis in rats

Quercetin relieves symptoms in mice with reflux esophagitis (RE), but the mechanism is unclear. Quercetin attenuates esophageal mucosal inflammation in RE mice by inhibiting the production of inflammatory factors IL-β and IL-6. In addition, using transcriptomic and metabolomic analyses, we found ...

2025-04-03 | MTBLS12138 | MetaboLights
MetabolomicsQuercetin alleviates ETEC K88-induced host injury by driving the circulation and fluctuation of AHL-like quorum-sensing signaling molecules in the blood–liver–colon system

Abstract:

Background: Quercetin is a flavonoid with various probiotic properties, demonstrating anti-inflammatory, anti-oxidative, anti-cancer, and anti-obesity effects in humans and animals. However, quercetin’s effect on enterotoxigenic Escherichia coli (ETEC) K88-induced host body injury...

2026-01-14 | MTBLS13677 | MetaboLights
TranscriptomicsHepatic gene expression in BALB/c mice fed a quercetin diet
We showed that diets containing 0.1% or 0.5% quercetin lowered the STZ-induced increase in blood glucose levels and improved plasma insulin levels. A cluster analysis of the hepatic gene expressions showed that 0.5% quercetin diet suppressed STZ-induced alteration of gene expression. Gene set enri...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-38136 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression in streptozotocin-induced diabetic mice fed a quercetin diet
Quercetin is a food component that may ameliorate the diabetic symptoms. We examined hepatic gene expression of BALB/c mice with streptozotocin (STZ)-induced diabetes to elucidate the mechanism of the protective effect of dietary quercetin on diabetes-associated liver injury. We fed STZ-induced dia...
ORGANISM(S): Mus musculus 
2012-05-22 | E-GEOD-38067 | biostudies-arrayexpress
TranscriptomicsTranscription profiling and proteomic profiling of rat colon mucosa from rats fed quercetin
Quercetin has been shown to act as an anti-carcinogen in experimental colorectal cancer (CRC). The aim of the present study was to characterise transcriptome and proteome changes occurring in the distal colon mucosa of rats supplemented with 10 g quercetin/kg diet for 11 weeks. Transcriptome data an...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7479 | biostudies-arrayexpress
TranscriptomicsQuercetin suppresses immune cell accumulation and improves mitochondrial gene expression in epididymal adipose tissue of diet-induced obese mice
We examined the effect of quercetin on the gene expression and function of epididymal adipose tissue (EAT) in Western diet-induced obese mice. Quercetin suppressed the increase in the number of macrophages and the decrease in the ratio of CD4+ to CD8+ T cells in EAT, and the elevation of plasma lept...
ORGANISM(S): Mus musculus 
2016-02-25 | E-GEOD-71367 | biostudies-arrayexpress
Transcriptomicstranscription profiling by array of C57BL/6J mice fed a Western-style diet with or without 0.05% quercetin against mice on a control diet to study the effect of quercetin on obesity and hepatic gene expression
To determine the effect of consumption of a quercetin-rich diet on obesity and dysregulated hepatic gene expression, C56BL/6J mice were fed for 20 weeks on control or a Western diet high in fat, cholesterol and sucrose, both with or without 0.05% quercetin. Chronic dietary intake of quercetin reduce...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-38141 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Caco-2 cell differentiation by ascorbate-stabilized quercetin
The aim was to investigate mechanisms contributing to quercetin’s previously described effects on cell-proliferation and -differentiation, which contradicted its proposed anti-carcinogenic potency. In a 10-day experiment, 40 µM quercetin stabilized by 1mM ascorbate reduced Caco-2 differentiation ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7259 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of C. elegans exposed to quercetin and tannic acid
Recent research has highlighted that the polyphenols Quercetin (Q) and Tannic acid (TA) are capable of extending the lifespan of C. elegans. To gain a deep understanding of the underlying molecular genetics, we analyzed the global transcriptional patterns of nematodes exposed to Quercetin or Tannic ...
ORGANISM(S): Caenorhabditis elegans 
2012-02-03 | E-GEOD-35354 | biostudies-arrayexpress
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