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Gene expression profile variation between 4 BCR-Abl transduced cell lines:
1-Mouse DA1-3b cell line as reference,
2-DR1 imatinib resistant clone with E255K BCR-abl mutation
3-DRBMSR 2 dasatinib resistant clone with E255K and T315I BCR-Abl mutation.
4-DRBMSR 7 dasatinib resistant cl...
ORGANISM(S): Mus musculus 
Characterization of structural genomic alteration in new-generated dasatinib and imatinib mouse BCR-ABL resistant cell line
ORGANISM(S): Mus musculus 
In this dataset are the data from : - 17 patients studied by WGS - 49 patients studied by WES - 9 (/49) patients studied by RNASeq at 2 time points - the same 9 patients studied by ERRBS at 2 time points
We first performed a comprehensive analysis of the genome of 66 chronic myelomonocytic leukemia cases using whole exome (N=49) or whole genome (N=17) sequencing for paired leukemic-control DNA. Then, we realized serial analysis of whole exome sequence in 17 cases, completed with serial RNA sequencin...
Data Access Committee EGAC00001000342
The TET2 locus was analyzed for DNA copy number, and LOH using a large set of paired samples (n=106), i.e. AML cells at diagnosis and normal peripheral blood mononuclear cells at remission; and AML at diagnosis (n=6). Affymetrix 6.0 SNP array were used.
ORGANISM(S): Homo sapiens 
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