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Detection of queuosine and queuosine precursors in tRNAs by direct RNA sequencing
Glycosylation of queuosine in tRNAs contributes to optimal translation and post-embryonic growth in vertebrates
Queuosine (Q) is a complex tRNA modification found at position 34 of four tRNAs with a GUN anticodon, and it regulates the translational efficiency and fidelity of the respective codons that differ at the Wobble position. In bacteria, the biosynthesis of Q involves two precursors, preQ0 and preQ1, w...
ORGANISM(S): Escherichia coli Schizosaccharomyces pombe synthetic construct 
2023-09-19 | GSE236838 | GEO
Analysis of queuosine and 2-thio tRNA modifications by high throughput sequencing
Post-transcriptional modification of tRNAs is critical for protein synthesis. Queuosine (Q), a 7-deaza-guanosine derivative, is present at the first position of anticodons of several tRNA species. In vertebrate tRNAs for Tyr and Asp, Q is further glycosylated with galactose and mannose to generate g...
ORGANISM(S): Homo sapiens 
2023-11-21 | GSE213181 | GEO
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