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TranscriptomicsTranscriptional responses of human monocyte-derived macrophages (HMDM) to lipopolysaccharide (LPS)
Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing inter-species differences in the transcriptional responses of primary human and mouse macrophages to the TLR4 agon...
ORGANISM(S): Homo sapiens 
2012-03-28 | E-GEOD-19482 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of mouse BMM and TEPM to lipopolysaccharide (LPS)
Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing inter-species differences in the transcriptional responses of primary human and mouse macrophages to the TLR4 agon...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-19490 | biostudies-arrayexpress
TranscriptomicsMyeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-M-NM-:B gene network
Chromosome 5q deletions (del(5q)) are common in high-risk (HR) Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML); however, the gene regulatory networks that sustain these aggressive diseases are unknown. Reduced miR-146a expression in del(5q) HR-MDS/AML and miR-146a-/- hematopoietic st...
ORGANISM(S): Homo sapiens 
2014-08-23 | E-GEOD-60649 | biostudies-arrayexpress
TranscriptomicsAfter demyelination in the adult CNS, oligodendrocyte precursor cells revert to an immature mRNA profile and express immune cues favoring their migration
In multiple sclerosis (MS) and experimental models of demyelination, myelin repair is mostly achieved by oligodendrocyte precursor cells (OPCs). To gain insight into the biological specificity of these adult precursors, in the perspective to better understand why remyelination often fails in MS, we ...
ORGANISM(S): Mus musculus 
2014-11-06 | E-GEOD-48872 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis mutant REVOLUTA (HDZIPIII) to identify downstream targets
The establishment of ad/abaxial polarity is a fundamental event in plant development. It is critical for correct polar development of the leaf (the upper portion of the leaf is chloroplast rich and optimized for light capture while the lower portion is optimized for gas exchange) and for creating a...
ORGANISM(S): Arabidopsis thaliana 
2008-06-15 | E-GEOD-7003 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of E. coli steady-state cultures grown at different aerobiosis levels
E. coli steady-state cultures were grown at different aerobiosis levels; transcriptomic profiling was carried out of these cultures to measure oxygen-dependent gene expression using a reference-design microarray format.
ORGANISM(S): Escherichia coli 
2010-12-15 | E-MTAB-285 | biostudies-arrayexpress
TranscriptomicsE. coli Anaerobic/aerobic transitions in chemostat
Gene-expression measurements were made over a 20 minute time course as steady state E. coli cells were subjected to an anaerobic to aerobic or an aerobic to anaerobic environmental change.
ORGANISM(S): Escherichia coli 
2012-07-17 | E-MTAB-996 | biostudies-arrayexpress
TranscriptomicsConservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages
This SuperSeries is composed of the following subset Series: GSE19482: Transcriptional responses of human monocyte-derived macrophages (HMDM) to lipopolysaccharide (LPS) GSE19490: Transcriptional responses of mouse BMM and TEPM to lipopolysaccharide (LPS) GSE19765: Transcriptional responses of human...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-19492 | biostudies-arrayexpress
TranscriptomicsNrf2b: a novel zebrafish paralog of the oxidant-responsive transcription factor Nrf2.
We identified a novel paralog of the antioxidant response element transcription factor, Nrf2 in zebrafish. To determine whether the paralogs Nrf2a and Nrf2b regulate different sets of genes, we performed loss-of-function experiments followed by microarray-based gene expression profiling, performed ...
ORGANISM(S): Danio rerio 
2011-12-20 | E-GEOD-32594 | biostudies-arrayexpress
GenomicsMacroH2A1 ChIP-seq from IMR90 human primary lung fibroblasts
The histone variant macroH2A1 and the poly(ADP-ribose) polymerase PARP-1 both regulate gene transcription by modulating chromatin structure and function. Of the two macroH2A1 splice variants, macroH2A1.1 and macroH2A1.2, the former is often suppressed in cancer and has the unique ability to interact...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-54845 | biostudies-arrayexpress
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