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TranscriptomicsGenome-wide profiling of miRNA expression dynamics in monocyte-derived dendritic cells following infection with a panel of intra-cellular bacteria
We report the application of RNA sequencing to assess the expression dynamics of miRNAs and their isoforms over time upon infection with a panel of six intracellular bacteria (Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis Beijing strain GC1237, Mycobacterium bovis BCG, Salmonella typh...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-64142 | biostudies-arrayexpress
TranscriptomicsStandardized whole-blood transcriptional profiling enables the deconvolution of complex induced immune responses
The study employs a standardized whole-blood stimulation systems to test the hypothesis that responses to Toll-like receptor ligands or whole microbes can be defined by the combined transcriptional signatures of key effector cytokines. The study encompasses the analysis of 21 distinct whole blood st...
ORGANISM(S): Homo sapiens 
2016-08-04 | E-GEOD-85176 | biostudies-arrayexpress
GenomicsGEH Data Access Committee
Data Access Committee EGAC00001000139
EGAC00001000139 | EGA
Genomicsena-DATASET-IP-27-09-2016-09:44:13:032-494 - samples
We recruited 100 healthy, male donors of self-reported European descent (EUB) and 100 of self-reported African descent (AFB) (Ghent, Belgium). For each participant, peripheral blood mononuclear cells (PBMCs) were isolated from whole blood on Ficoll-Paque density gradients. Monocytes were then positi...
EGAD00001002714 | EGA
GenomicsGenome-wide SNP genotyping of Central African rainforest hunter-gatherers and neighbouring agriculturalists
The emergence of agriculture in West-Central Africa, ~5,000 years ago, profoundly modified the cultural landscape and mode of subsistence of most sub-Saharan populations. How this major innovation has impacted the genetic history of rainforest hunter-gatherers — historically referred to as “pygmies”...
EGAS00001000605 | EGA
GenomicsGenetic control of the transcriptomic response of monocytes to bacterial and viral stimuli assessed by RNA-seq in Africans and Europeans
Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the extent of population differences in immune responses, and their genetic and evolutionary determinants, remain undefined. Here, we characterized, using RNA-sequencing, the transcriptional response of primary mon...
EGAS00001001895 | EGA
GenomicsEvolution of the African pygmy phenotype
The evolutionary history of the human ‘pygmy’ phenotype (small body size), a characteristic of African and Southeast Asian rainforest hunter-gatherers, is largely unknown. Here we use a genome-wide admixture mapping analysis to identify 16 genomic regions that are significantly associated with the p...
EGAS00001000908 | EGA
GenomicsEvolution of the African pygmy phenotype
Data Access Committee EGAC00001000216
EGAC00001000216 | EGA
GenomicsGenome-wide genotyping data and exome sequencing of 100 European-descent and 100 African-descent Belgians used in the EGAS000010
The 100 European-descent (EUB) and 100 African-descent (AFB) Belgians studied were genotyped for a total of 4,301,332 SNPs on the Illumina HumanOmni5-Quad BeadChips. Whole-exome sequencing was carried out for the same 200 individuals with the Nextera Rapid Capture Expanded Exome kit, on the Illumina...
EGAD00010001131 | EGA
GenomicsGenome-wide SNP genotyping and DNA methylation epigenotyping of African rainforest hunter-gatherers and neighbouring agriculturalists
The epigenomic landscape of the human genome, in particular DNA methylation, is increasingly recognised as an important driver of phenotypic diversity in health and disease. However, the impact that genetic variation and changes in lifestyle and ecological habitat have on this epigenetic mark remain...
EGAS00001001066 | EGA
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