Sort   by:  
 Page size 
ProteomicsHUVEC endosome LCMS - ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
Complement promotes vascular inflammation in transplant organ rejection and connective tissue diseases. Here we identify ZFYVE21 as a complement-induced Rab5 effector that regulates pro-inflammatory non-canonical NF-B signaling in endothelial cells (EC). In response to membrane attack complexes (MAC...
ORGANISM(S): Homo sapiens (Human) 
2019-04-09 | PXD013381 | Pride
Rab5 mac 
TranscriptomicsKlf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated membrane Beta1/Beta2-integrin expression
The Kruppel-like factor 5 (Klf5) regulates pluripotent stem cell self-renewal but its role in somatic stem cells is unknown. Klf5 deficient hematopoietic stem cells and progenitors (HSC/P) fail to engraft after transplantation. This HSC/P defect was associated with impaired bone marrow (BM) homing a...
ORGANISM(S): Mus musculus 
2013-01-30 | E-GEOD-43806 | biostudies-arrayexpress
ProteomicsRab5a-VPS34 unnatural amino acid mediated crosslinking
The small GTPase Rab5 has an essential role in sorting vesicles arriving to and leaving the early endosome. One key function of Rab5 in this process is the activation of the primordial phosphatidylinositol 3-kinase VPS34, a lipid kinase that phosphorylates phosphatidylinositol (PI) to generate PI3P....
ORGANISM(S): Homo Sapiens (human) 
2021-12-21 | PXD023533 | JPOST Repository
ModelsDel_Conte_Zerial2008_Rab5_Rab7_cut_out_switch
Cut-out switch model Membrane identity and GTPase cascades regulated by toggle and cut-out switches Perla Del Conte-Zerial, Lutz Brusch, Jochen C Rink, Claudio Collinet, Yannis Kalaidzidis, Marino Zerial, and Andreas Deutsch: ...
2024-09-02 | BIOMD0000000174 | BioModels
GenomicsMicrotubule-RAB5 mutual-influential system screening based on gene-regulatory networks map in Rab5 RNAi eye-degeneration model
Microtubule-RAB5 mutual-influential system screening based on gene-regulatory networks map in Rab5 RNAi eye-degeneration model
PRJNA1141174 | ENA
TranscriptomicsGene Expression in mice liver after knockdown of Rab5
RNAi-mediated silencing of Rab5 and the consequent loss of endosomes in the mouse liver caused severe metabolic defects such as hypoglycemia, hepatomegaly, hypercholesterolemia, hyperlipidemia and glycogen accumulation. Gene expression in mice liver after knockdown of Rab5 has been performed the Mou...
ORGANISM(S): Mus musculus 
2015-05-03 | E-GEOD-67227 | biostudies-arrayexpress
ProteomicsA novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution
RAB5-GTP activation of the multiprotein VPS34 complex II (VPS34-CII) is critical for endosomal sorting and maturation, phagocytosis, and receptor downregulation. RAB5-GTP activates VPS34-CII, by binding to a helical insertion in the C2 domain of VPS34 on the BECLIN1/UVRAG-containing adaptor arm of t...
ORGANISM(S): Homo sapiens (Human) 
2026-05-26 | PXD061277 | Pride
TranscriptomicsMicrotubule-RAB5 mutual-influential system screening based on gene-regulatory networks map in Rab5 RNAi eye-degeneration model
Rabs are involved in neuronal development and protrusion formation. Existing studies support the notion that manipulation or mutation of Rab genes could lead to functional changes in neurons. However, whether Rabs gene-manipulation induced Drosophila eye-degeneration remains unknown. By down-regulat...
ORGANISM(S): Drosophila melanogaster 
2026-07-28 | GSE273282 | GEO
TranscriptomicsGene Expression in mice liver after knockdown of Rab5
RNAi-mediated silencing of Rab5 and the consequent loss of endosomes in the mouse liver caused severe metabolic defects such as hypoglycemia, hepatomegaly, hypercholesterolemia, hyperlipidemia and glycogen accumulation. Gene expression in mice liver after knockdown of Rab5 has been performed the Mou...
ORGANISM(S): Mus musculus 
2015-05-03 | GSE67227 | GEO
GenomicsRNA-seq analysis of human CD19 CAR T cells overexpressing RAB5
RNA-seq analysis of human CD19 CAR T cells overexpressing RAB5
PRJNA1124067 | ENA
Sort   by:  
 Page size