Sort   by:  
 Page size 
ProteomicsHUVEC endosome LCMS - ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
Complement promotes vascular inflammation in transplant organ rejection and connective tissue diseases. Here we identify ZFYVE21 as a complement-induced Rab5 effector that regulates pro-inflammatory non-canonical NF-B signaling in endothelial cells (EC). In response to membrane attack complexes (MAC...
ORGANISM(S): Homo sapiens (Human) 
2019-04-09 | PXD013381 | Pride
Rab5 mac 
UnknownZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes.
Not available
S-EPMC6529429 | biostudies-literature
UnknownComplement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ-Primed Human Endothelium.
Not available
S-EPMC6557295 | biostudies-literature
UnknownComplement-activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells.
Not available
S-EPMC7324183 | biostudies-literature
TranscriptomicsSingle-cell RNA-seq analysis of FACS-sorted CD41+ bone marrow cells from WT and gunmetal mice
Protein prenylation is essential for membrane targeting of signaling and trafficking proteins. We identified a recurrent homozygous RABGGTA missense variant (L235F) in 23 patients from 19 consanguineous families with a severe multisystem disorder characterized by bicytopenia, recurrent infections, s...
ORGANISM(S): Mus musculus 
2026-09-28 | E-MTAB-17643 | biostudies-arrayexpress
GenomicsThe DAXX/ATRX Complex Protects Tandem Repetitive Elements in the Absence of DNA Methylation by Promoting H3K9 Trimethylation [ChIP-Seq]
In mammals, DNA methylation is essential for protecting repetitive sequences from aberrant transcription, translocation, and homologous recombination. However, DNA hypomethylation occurs during specific developmental stages (e.g. preimplantation embryos) and in certain cell types (e.g., primordial g...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-70811 | biostudies-arrayexpress
Sort   by:  
 Page size