Bacterial genomes are shaped by cryptic prophages, which are viral genomes integrated into the bacterial chromosome. Escherichia coli genomes have 10 prophages on average. Though usually inactive, prophage genes can profoundly impact host cell physiology. Among the phage genes in the E. coli chromos...
Regulatory protein from a restriction-modification system interferes with E. coli global regulatory networks, revealing an unexpected link between excision of a cryptic Rac prophage and lipopolysaccharide biosynthesis defects