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GenomicsClonal expansion analysis of transposon insertions by high-throughput sequencing identifies candidate cancer genes in a PiggyBac mutagenesis screen
Somatic transposon mutagenesis in mice is an efficient strategy to investigate the genetic mechanisms of tumorigenesis. The identification of tumor driving transposon insertions traditionally requires the generation of large tumor cohorts to obtain information about common insertion sites. Tumor dri...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-46210 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of mouse differentiating embryonic stem cells
To characterise changes in microRNA expression in differentiating mouse ES cells
ORGANISM(S): Mus musculus 
2009-08-15 | E-TABM-621 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of differentiating mouse embryonic stem cells
To characterize messenger RNA expression in differentiating mouse ES cells
ORGANISM(S): Mus musculus 
2009-08-15 | E-TABM-620 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human cancer cell lines upon ZMPSTE24 silencing
Defining the aging-cancer relationship is a challenging task. Mice deficient in Zmpste24, a metalloproteinase mutated in human progeria and involved in nuclear prelamin A maturation, recapitulate many features of aging. However, their short lifespan and cell-intrinsic and -extrinsic alterations rest...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-41799 | biostudies-arrayexpress
GenomicsEGAS00001000814-sc-20150331 - samples
The aim of this study is to ascertain whether leukaemic mutations exist within the blood of people with otherwise normal haematopoeisis. To satisfy this aim we plan to look for 7 known leukaemic mutations in the whole blood DNA of a large cohort of blood donors who have normal haematopoesis. Genom...
EGAD00001001319 | EGA
GenomicsStudy to investigate the prevalence of leukaemic mutations in whole blood DNA in a cohort of blood donors
The aim of this study is to ascertain whether leukaemic mutations exist within the blood of people with otherwise normal haematopoeisis. To satisfy this aim we plan to look for 7 known leukaemic mutations in the whole blood DNA of a large cohort of blood donors who have normal haematopoesis. Genom...
EGAS00001000814 | EGA
ProteomicsDirect identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leukocyte antigens (HLA) on the surface of native tumor tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the mel...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-01-30 | MSV000080517 | MassIVE
ProteomicsMass spectrometry-based draft of the mouse proteome
Quantitative draft map of the proteomes of 41 healthy tissues of the animal model Mus musculus and a panel of 66 murine pancreatic ductal adenocarcinoma cell lines and. Our in-depth analysis provides evidence for proteins encoded by >16,000 genes (~76% of the total annotated protein-coding genes), w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-09 | MSV000089856 | MassIVE
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