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GenomicsA unique chromatin signature uncovers early developmental enhancers in humans
Cell fate transitions involve integration of genomic information encoded by regulatory elements, such as enhancers, with the cellular environment. However, identification of the genomic sequences that control the earliest steps of human embryonic development represents a formidable challenge. Here w...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-GEOD-24447 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [scRNA-seq]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2026-07-12 | E-MTAB-17228 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [Micro-C]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15688 | biostudies-arrayexpress
GenomicsGenome-wide analysis of p300, H3K4me3, H3K4me1, H3K27me3 and H3K27ac in in vitro differentiated human neural crest cells (hNCC)
Combining an in vitro hNCC differentiation protocol with epigenomic profiling, we provide the first whole-genome characterization of cis-regulatory elements in this highly relevant cell type. With this data at hand, we have characterized the chromatin state and dynamics of all human gene promoters d...
ORGANISM(S): Homo sapiens 
2012-09-13 | E-GEOD-28874 | biostudies-arrayexpress
TranscriptomicsFoxd3 promotes the exit from naïve pluripotency and prevents germline specification through enhancer decommissioning
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-09-14 | E-GEOD-70547 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiments in human neural crest cells (hNCC)
Combining an in vitro hNCC differentiation protocol with epigenomic profiling, we provide the first whole-genome characterization of cis-regulatory elements in this highly relevant cell type. With this data at hand, we have characterized the chromatin state and dynamics of all human gene promoters d...
ORGANISM(S): Homo sapiens 
2012-09-13 | E-GEOD-28875 | biostudies-arrayexpress
GenomicsEpigenomic profiling of enhancers identifies orphan nuclear receptors NR2F1 and NR2F2 as novel regulators of human neural crest.
Combining an in vitro hNCC differentiation protocol with epigenomic profiling, we provide the first whole-genome characterization of cis-regulatory elements in this highly relevant cell type. With this data at hand, we have characterized the chromatin state and dynamics of all human gene promoters d...
ORGANISM(S): Gallus gallus 
2012-09-13 | E-GEOD-38066 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human cell line HepG2 with anti-Histone H3 acetyl K9/14, USF1 antibody, USF2 antibody and normal rabbit IgG
Whole genome ChIP-chip study using human liver cell line HepG2 and anti-Histone H3 acetyl K9/14 (06-599); USF1 antibody (H-86, sc-8983); USF2 antibody (C-20, sc-862) and normal rabbit IgG (12-370). Three completely independent biological replicates were performed for each antibody, obtaining the cor...
ORGANISM(S): Homo sapiens 
2007-11-30 | E-TABM-314 | biostudies-arrayexpress
GenomicsFoxd3 promotes the exit from naïve pluripotency and prevents germline specification through enhancer decommissioning [ChIP-Seq]
Following implantation, mouse epiblast cells transit from a naïve to a primed state in which they are competent for both somatic and primordial germ cell (PGC) specification. Using mouse embryonic stem cells (mESC) as an in vitro model to study the transcriptional regulatory principles orchestrating...
ORGANISM(S): Mus musculus 
2015-09-14 | E-GEOD-70545 | biostudies-arrayexpress
TranscriptomicsFoxd3 promotes the exit from naïve pluripotency and prevents germline specification through enhancer decommissioning [RNA-Seq]
Following implantation, mouse epiblast cells transit from a naïve to a primed state in which they are competent for both somatic and primordial germ cell (PGC) specification. Using mouse embryonic stem cells (mESC) as an in vitro model to study the transcriptional regulatory principles orchestrating...
ORGANISM(S): Mus musculus 
2015-09-14 | E-GEOD-70546 | biostudies-arrayexpress
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