Radiation-induced lung injury

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Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China (1)
Dept. of Radiation Oncology, Medical Sciences I, B146B, University of California Irvine, CA 92697-2695 (1)

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Berberine alleviates radiation-induced lung injury through promoting microbiota-derived inosine via gut-lung axis

Radiation-induced lung injury (RILI) is a major complication of thoracic radiotherapy. A previous study has indicated an association between berberine (BBR) and reduced incidence of RILI. However, the underlying mechanisms remain unknown. Here we validated the radioprotective role of BBR in mouse...

2025-05-14 | MTBLS12391 | MetaboLights

Fecal Microbiota Transplantation Restores Gut Homeostasis and Enhances ER-Phagy to Mitigate Radiation-Induced Lung Injury

Radiation-induced lung injury (RILI) is a severe side effect of radiation therapy, characterized by lung tissue damage, inflammation, and organ dysfunction. Although fecal microbiota transplantation (FMT) has shown potential in alleviating radiation-induced damage, its underlying mechanisms ...

2026-01-05 | MTBLS12699 | MetaboLights

A human alveolus-on-chip model for radiation induced lung injury

PRJNA1014392 | ENA

Unraveling the Temporal Dynamics of Radiation-Induced Lung Injury

PRJNA1255119 | ENA

A human alveolus-on-chip model for studying radiation induced lung injury

PRJNA1015133 | ENA

Type I IFN Drives ILC2 to ILC1 Plasticity in Radiation-Induced Lung Injury

PRJNA1334384 | ENA

Senescence gene signature of radiation fibrosis

Radiation lung injury is characterized by early inflammation and late fibrosis. The causes underlying the chronic, progressive nature of radiation injury are poorly understood. Here, we report that the gene expression of irradiated lung tissue correlates with that observed in the lungs in aged anim...

ORGANISM(S): Mus musculus

2013-11-01 | E-GEOD-41789 | biostudies-arrayexpress

Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through Notch signaling

PRJNA789539 | ENA

Study of molecular mechanisms in lung injury due to ultra-high and conventional dose rate pulsed radiation based on 4D-DIA proteomics

Objective: To investigate the mechanism of ultra-high dose rate pulsed radiation in radiation-induced lung injury (RILI), providing an experimental and theoretical basis for the application of FLASH-RT in radiotherapy. Methods: C57BL/6J mice were randomly divided into three groups: a sham group, a F...

ORGANISM(S): Mus musculus (Mouse)

2025-05-07 | PXD057784 | Pride

Critical Role of Sphingolipid Pathway Components in Murine Radiation-Induced Lung Injury: Protection by Sphingosine-1-Phosphate Analogues

Clinically significant radiation-induced lung injury (RILI) is associated with significant morbidity and mortality and a common toxicity in patients administered thoracic radiotherapy. While the molecular etiology of RILI is poorly understood, we previously characterized a murine model of RILI in wh...

ORGANISM(S): Mus musculus

2010-11-17 | E-GEOD-25295 | biostudies-arrayexpress

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