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TranscriptomicsExpression data from healthy control human peripheral blood mononuclear cells (PBMC) treated with wild-type IL-2 or F42K
IL-2 mutant (F42K) is a variant of IL-2 that binds preferentially to the lower affinity IL-2Rβγ and has minimal binding to CD25, on Tregs, effector NK and T-cell subsets. Our recent study has uncovered that in contrast to WT IL-2, F42K did not efficiently induce the expansion of highly suppressive...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-77601 | biostudies-arrayexpress
TranscriptomicsExpression data from FACS-sorted CD8+BTLA+ vs CD8+BTLA- Human Tumor-infiltrating Lymphocytes in Metastatic Melanoma
Adoptive T-cell Therapy (ACT) involves using tumor-infiltrating lymphocytes (TIL) isolated from metastatic melanoma and expanding them ex vivo prior to infusion into lympho-depleted patients. This is one of the most promising approaches to treat metastatic melanoma, with the rates of clinical respo...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-43260 | biostudies-arrayexpress
UnknownLow-burden TP53 mutations represent frequent genetic events in CLL with an increased risk for treatment initiation.
Not available
S-EPMC10766018 | biostudies-literature
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