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MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
TranscriptomicsNucleosome positioning in H3S57 mutants in yeast
In order to test the effect of H3S57 phosphorylation on nucleosome positioning in yeast, nucleosome were mapped in a WT strain, a strain with H3S57A mutation (phospho absent) and a strain H3S57E mutation (phospho mimicking).
ORGANISM(S): Saccharomyces cerevisiae 
2020-12-20 | E-MTAB-6901 | biostudies-arrayexpress
TranscriptomicsChromatin structure changes upon oxidative stress or UV irradiation in the yeast Saccharomyces cerevisiae
Development of molecular approaches based on chromosome conformation capture (3C) technology such as Hi-C, combined with methods for modeling and interpreting chromatin interaction data, have revolutionized the analysis of chromosome folding. Even if the impact of chromatin structure on gene express...
ORGANISM(S): Saccharomyces cerevisiae 
2020-12-20 | E-MTAB-5825 | biostudies-arrayexpress
GenomicsNanopore sequencing on yeast expressing 4 murine DNMTs
Localisation of CpG methylation in yeast expressing murine DNMTS Genomic DNA was purified from a control strain and a strain expressing murine DNMTs
ORGANISM(S): Saccharomyces cerevisiae 
2020-09-30 | E-MTAB-9356 | biostudies-arrayexpress
Genomicsena-DATASET-Hospital Clinic Barcelona-12-08-2015-11:33:40:243-146 - samples
Exome Sequencing. 3 μg of genomic DNA from each sample were sheared and used for the construction of a paired-end sequencing library as described in the paired-end sequencing sample preparation protocol provided by Illumina41. Enrichment of exonic sequences was then performed for each library usi...
EGAD00001001464 | EGA
Genomicsena-DATASET-Hospital Clinic Barcelona-21-07-2015-12:09:53:274-78 - samples
RNASeq sequencing. Each library was sequenced using TruSeq SBS Kit v3-HS, in paired-end mode with a read length of 2 × 76 bp. We generated more than 20 million paired-end reads for each sample in a fraction of a sequencing lane on HiSeq2000 (Illumina Inc.) following the manufacturer’s protoc...
EGAD00001001443 | EGA
Genomicsena-DATASET-Hospital Clinic Barcelona-13-08-2015-12:02:30:199-229 - samples
Whole Genome sequencing. 2 μg of genomic DNA from each sample was used for the construction of two short-insert paired-end sequencing libraries. Both types of libraries were sequenced in paired-end mode on Illumina GAIIx (2 × 151 bp) using Sequencing kit v4 or Illumina HiSeq2000 (2x101 bp) usi...
EGAD00001001466 | EGA
GenomicsU219-array-CLL-EGAS00001001306
CLL Expression Array
EGAD00010000875 | EGA
GenomicsIntegrated Genomic Analysis of Chronic Lymphocytic Leukaemia
Chronic lymphocytic leukaemia (CLL) is a frequent and heterogeneous disease whose genetic alterations determining the clinicobiological behaviour are not fully understood. Here, we describe a comprehensive evaluation of the genomic landscape of 452 CLLs and 54 monoclonal B-lymphocytosis (MBL), a pre...
EGAS00001001306 | EGA
TranscriptomicsEffective sorafenib treatment response in a panel of genomically-characterized malignant peripheral nerve sheath tumor orthoxenograft models
Background: Malignant peripheral nerve sheath tumors (MPNST) are soft-tissue sarcomas that can arise either sporadically or in association with neurofibromatosis type 1 (NF1). These aggressive malignancies confer poor survival, with no effective therapy available. Methods: We generated five patient-...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-60082 | biostudies-arrayexpress
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