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ProteomicsFunctional Effects of Extracellular Vesicles Altered by a Per- and Polyfluoroalkyl Substance Mixture: Liver Cell Proteomic Expression Alterations
Extracellular vesicles (EVs) have emerged as key molecules in cellular processes and diseases. The intersection of environmental exposures and EVs has recently gained attention, with EVs being highlighted as biomarkers of exposure, as well as mediators of environmental exposure-induced disease. The ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD050095 | Pride
In vitro Environmental health Extracellular vesicles Proteomics Pfas Liver 
TranscriptomicsOzone Exposure Alters MicroRNA Expression Profiles in Humans
We set out to test the hypothesis that ozone inhalation exposure significantly alters miRNA expression profiles within the airway of humans. Adult human volunteers were exposed to 0.4 ppm ozone for two hours. Induced sputum samples were collected from each subject 48 hours pre-exposure and 6 hours p...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-47977 | biostudies-arrayexpress
ProteomicsCharacterization of equine bronchoalveolar lavage fluid extracellular vesicle proteomes across four isolation methods
Growing evidence supports the importance of extracellular vesicle (EV) as mediators of communication in pathological processes, including those underlying respiratory disease. However, establishing methods for isolating and characterizing EVs remains challenging, particularly for respiratory samp...
ORGANISM(S): Equus caballus (Horse) 
2025-05-07 | PXD054702 | Pride
Methods optimization Respiratory Bronchoalveolar lavage Extracellular vesicles Equine Proteome Cell surface markers Lc-ms/ms 
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Agilent]
MicroRNAs (miRNAs) are critical regulators of gene expression, yet much remains unknown regarding miRNA changes resulting from environmental exposures and whether they influence pathway signaling across various tissues and time. To gain knowledge on these novel topics, we set out to investigate in v...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42393 | biostudies-arrayexpress
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Affymetrix]
In addition to gaining knowledge on in vivo miRNA responses to formaldehyde, we set out to relate these miRNA responses to transcriptional profiles modified by formaldehyde. Rats were exposed by inhalation to either 0 or 2 ppm formaldehyde (6 hours/day) for 28 days. Genome-wide transcriptional profi...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42394 | biostudies-arrayexpress
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