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UnknownTandem fluorescence imaging of dynamic S-acylation and protein turnover.
Not available
S-EPMC2889305 | biostudies-literature
TranscriptomicsRNAseq and Lariat sequencing of different S. pombe growth conditions
We performed lariat sequencing to profile the diversity of spliced RNA lariats in S. pombe identify annotated and alternate introns. Three different growth conditions were used to grow S. pombe wt and S. pombe Δdbr1. Lariat sequencing of the Δdbr1 strains and RNAseq of the wt and Δdbr1 strains were ...
ORGANISM(S): Schizosaccharomyces pombe 
2015-09-03 | E-GEOD-68345 | biostudies-arrayexpress
MetabolomicsA cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
Digoxin extracted from the foxglove plant is a widely prescribed natural product for treating heart failure. It is listed as an essential medicine by the World Health Organization. However, how the foxglove plant synthesizes digoxin is mostly unknown, especially the cytochrome P450 sterol side chain...
2025-07-03 | MTBLS7993 | MetaboLights
UnknownGenome-Wide Identification of Novel sRNAs in Streptococcus mutans.
Not available
S-EPMC9017351 | biostudies-literature
TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutant
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-07-04 | E-GEOD-11696 | biostudies-arrayexpress
TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutant complemented with an N-terminal Flag espR gene
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-08-08 | E-GEOD-12379 | biostudies-arrayexpress
TranscriptomicsComparative analysis of the gene expression profiles of M.tuberculosis espR (Rv3849) transposon and knockout mutants
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-12381 | biostudies-arrayexpress
TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutants containing N- or C-terminal mutations in the espR gene
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-12380 | biostudies-arrayexpress
TranscriptomicsWT macrophage response to transfected bacterial ligands
Transcriptional profiling of WT macrophages transfected with L. monocytogenes genomic DNA, synthetic MDP, or both Keywords: Ligand comparison. Experiment in WT background, with different combinations of bacterial ligands. Multiple biological replicates (see array names), with one replicate per arra...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-8103 | biostudies-arrayexpress
UnknownTumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
Not available
S-EPMC5018213 | biostudies-literature
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