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ProteomicsThe Ragulator complex regulates NLRP3 inflammasome activation through interaction with HDAC6
The activation of the NLRP3 inflammasome is spatiotemporally orchestrated by various organelles, but the precise roles of lysosomes are still unclear. Here we show the vital role of the Ragulator complex, a lysosomal protein, in NLRP3 inflammasome activation. Deficiency of Lamtor1, an essential comp...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD033497 | Pride
Ragulator complex Hdac6 Nlrp3 inflammasome Α-tocopherol 
GenomicsControl of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
PRJNA742124 | ENA
UnknownDisruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.
Not available
S-EPMC4570232 | biostudies-literature
GenomicsThe Protein Complex Ragulator is the Substrate-specific Scaffold for mTORC1 to Regulate Transcription Factor EB
The Protein Complex Ragulator is the Substrate-specific Scaffold for mTORC1 to Regulate Transcription Factor EB
PRJNA719171 | ENA
UnknownHybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Not available
S-EPMC5722659 | biostudies-literature
TranscriptomicsThe Protein Complex Ragulator is the Substrate-specific Scaffold for mTORC1 to Regulate Transcription Factor EB
Mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is activated by nutrition sufficiency signals and extracellular growth signals. mTORC1 acts the hub that integrates these inputs to orchestrate number of cellular responses such as translation, nucleotide synthesis, lipid synthesis...
ORGANISM(S): Mus musculus 
2021-08-08 | GSE171357 | GEO
GenomicsLysosomal control of type I interferon induction via Ragulator-Rag complex [ATAC-seq]
Lysosomal control of type I interferon induction via Ragulator-Rag complex [ATAC-seq]
PRJNA1004404 | ENA
GenomicsLysosomal control of type I interferon induction via Ragulator-Rag complex [RNA-seq]
Lysosomal control of type I interferon induction via Ragulator-Rag complex [RNA-seq]
PRJNA1004405 | ENA
UnknownRagulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.
Not available
S-EPMC6156610 | biostudies-literature
OtherControl of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
The process of pyroptosis is mediated by inflammasomes and a downstream effector known as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N-terminal domain of GSDMD forms membrane pores that promote cytolysis. Numerous proteins promote GSDMD cleavage, but none are known t...
ORGANISM(S): Mus musculus 
2021-06-29 | GSE179089 | GEO
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