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ProteomicsThe Ragulator complex regulates NLRP3 inflammasome activation through interaction with HDAC6
The activation of the NLRP3 inflammasome is spatiotemporally orchestrated by various organelles, but the precise roles of lysosomes are still unclear. Here we show the vital role of the Ragulator complex, a lysosomal protein, in NLRP3 inflammasome activation. Deficiency of Lamtor1, an essential comp...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD033497 | Pride
Ragulator complex Hdac6 Nlrp3 inflammasome Α-tocopherol 
GenomicsThe Protein Complex Ragulator is the Substrate-specific Scaffold for mTORC1 to Regulate Transcription Factor EB
The Protein Complex Ragulator is the Substrate-specific Scaffold for mTORC1 to Regulate Transcription Factor EB
PRJNA719171 | ENA
GenomicsLysosomal control of type I interferon induction via Ragulator-Rag complex [RNA-seq]
Lysosomal control of type I interferon induction via Ragulator-Rag complex [RNA-seq]
PRJNA1004405 | ENA
GenomicsLysosomal control of type I interferon induction via Ragulator-Rag complex [ATAC-seq]
Lysosomal control of type I interferon induction via Ragulator-Rag complex [ATAC-seq]
PRJNA1004404 | ENA
TranscriptomicsThe Protein Complex Ragulator is the Substrate-specific Scaffold for mTORC1 to Regulate Transcription Factor EB
Mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is activated by nutrition sufficiency signals and extracellular growth signals. mTORC1 acts the hub that integrates these inputs to orchestrate number of cellular responses such as translation, nucleotide synthesis, lipid synthesis...
ORGANISM(S): Mus musculus 
2021-08-08 | GSE171357 | GEO
UnknownStructural basis for the assembly of the Ragulator-Rag GTPase complex.
Not available
S-EPMC5696360 | biostudies-literature
UnknownThe Ragulator complex and lysosomal calcium release are crucial for cell migration.
Not available
S-EPMC12152492 | biostudies-literature
UnknownHybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Not available
S-EPMC5722659 | biostudies-literature
UnknownThe Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia.
Not available
S-EPMC4731305 | biostudies-literature
UnknownThe Ragulator complex: delving its multifunctional impact on metabolism and beyond.
Not available
S-EPMC10175929 | biostudies-literature
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