Raj Monika M - OmicsDI

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4-ONE as a Chemoselective Biological Glue for Site-Resolved Protein Crosslinking and Proteomic Profiling

Protein crosslinking governs structure, stability, and interaction networks in biology, yet current chemical crosslinkers lack selectivity, produce heterogeneous products, and require pre-installed cleavable handles for analysis. Here, we report a conceptually distinct strategy that harnesses the in...

ORGANISM(S): Homo sapiens (Human)

2026-05-26 | PXD070252 | Pride

Cooperative Aldehyde Chemistry Maps an Orthogonal Lysine Reactivity Landscape

Reactive metabolites are often associated with nonspecific protein damage, if harnessed cooperatively they could be repurposed into precision tools for targeted labeling, redefining how we probe and manipulate protein function in complex biological systems. Here, we introduce a bioinspired cooperati...

ORGANISM(S): Homo sapiens (Human)

2026-04-14 | PXD067614 | Pride

Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

Not available

S-EPMC10957483 | biostudies-literature

Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.

Not available

S-EPMC11872607 | biostudies-literature

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

Not available

S-EPMC8830904 | biostudies-literature

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.