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TranscriptomicsTORC1 signaling pathway inhibition by rapamycin and caffeine affect lifespan, global gene expression and cell proliferation of fission yeast
Target of rapamycin complex 1 (TORC1) is implicated in growth control and aging from yeast to humans. Fission yeast is emerging as a popular model organism to study TOR signaling, although rapamycin has been thought to not affect cell growth in this organism. Here we analyzed the effects of rapamy...
ORGANISM(S): Schizosaccharomyces pombe 
2013-05-05 | E-MTAB-1489 | biostudies-arrayexpress
Transcriptomicswild-type and gaf1 mutant cells treated with Torin1 or with a combination of caffeine/rapamycin
Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and ageing. Inhibition of TORC1 leads to a down-regulation of factors that stimulate protein translation, which in turn contributes to longevity. TORC1-dependent post-transcriptional regulation of protein translation has been well studi...
ORGANISM(S): Schizosaccharomyces pombe 
2020-03-02 | E-MTAB-8569 | biostudies-arrayexpress
TranscriptomicsLaSSO, a strategy for genome-wide mapping of intronic lariats and branch-points using RNA-seq
Both canonical and alternative splicing of RNAs is governed by intronic sequence elements and produces transient lariat structures fastened by branch-points within introns. To map precisely the location of branch-points on a genomic scale, we developed LaSSO (Lariat Sequence Site Origin), a data-dri...
ORGANISM(S): Schizosaccharomyces pombe 
2014-03-18 | E-GEOD-50246 | biostudies-arrayexpress
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