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GenomicsNucleosomes are context-specific, H2A.Z modulated barriers to RNA polymerase
Nucleosomes are barriers to transcription in vitro, however, their effects on RNA polymerase in vivo are unknown. Here we describe a simple and general strategy to comprehensively map the positions of elongating and arrested RNA Polymerase II (RNAPII) at nucleotide resolution. Our results suggest th...
ORGANISM(S): Drosophila melanogaster 
2014-03-06 | E-GEOD-49106 | biostudies-arrayexpress
GenomicsThe budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo
High resolution ChIP-seq mapping, supported by in vitro reconstitution studies, suggests that the Cse4 nucleosome is a hemisome that occupies the ~80-bp AT-rich CDEII sequence. H4S47C-anchored cleavage mapping of S. cerevisiae centromeres
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-15 | E-GEOD-51949 | biostudies-arrayexpress
UnknownThrombotic Microangiopathy: An Under-Recognized Cause of CKD Following Viper Envenomation.
Not available
S-EPMC9171703 | biostudies-literature
UnknownDiscovery of potential small molecule inhibitors against β-hCG: an <i>in silico</i> study with <i>in vitro</i> validation.
Not available
S-EPMC12150210 | biostudies-literature
UnknownGut microbiome- targeted intervention ameliorates structural and transcriptomic changes in the kidney of hindlimb unloaded mouse model.
Not available
S-EPMC12817730 | biostudies-literature
UnknownMolecular mechanism of SLC5A8 inactivation in breast cancer.
Not available
S-EPMC3811868 | biostudies-literature
ProteomicsPLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production
Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory cancers. However, PLK1 overexpression in cancer does not correlate with drug sensitivity, and the clinical development of PLK1 inhibitors has been hampered by the lack of patient selection marker. Using a high-...
ORGANISM(S): Homo sapiens (Human) 
2022-03-08 | PXD031110 | Pride
Oxidative phosphorylation Mitochondria Plk1 Arid1a Synthetic lethality 
UnknownResearch priorities in Maternal, Newborn, & Child Health & Nutrition for India: An Indian Council of Medical Research-INCLEN Initiative.
Not available
S-EPMC5644295 | biostudies-literature
UnknownLiraglutide and Cardiovascular Outcomes in Type 2 Diabetes.
Not available
S-EPMC4985288 | biostudies-literature
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