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TranscriptomicsExpression profiling of MDR1+ and MDR1- human memory T cells from the blood and clinically-inflamed gut tissue
The aim of this study was to characterize the transcriptional signature of MDR1+ human memory T cells isolated from clinically inflamed gut tissue, and compare it to local MDR1- memory T cells Human mononuclear cells were isolated from the peripheral blood of a healthy adult donor (Ficol density cen...
ORGANISM(S): Homo sapiens 
2013-12-17 | E-GEOD-49702 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles of CCR7lo effector memory human T cell subsets
The aim of this study was to identify differentially-expressed genes in CCR4hi/CXCR3- and CCR4lo CXCR3+ CCR6+ human Th17 cell subsets Human CD45RO+ memory T cells isolated from the peripheral blood of healthy adult donors were sorted into 4 predominant CCR7lo CD25- effector memory subsets: (1) Th1 -...
ORGANISM(S): Homo sapiens 
2013-12-17 | E-GEOD-49703 | biostudies-arrayexpress
TranscriptomicsRNA elements in precursors instruct directional and processive primary piRNA biogenesis
PIWI-interacting RNAs (piRNAs) are animal gonad-specific small RNAs that control the activity of transposable elements. Long single stranded RNAs from a variety of sources are substrates for the nebulous primary processing pathway that converts these into thousands of 24-30 nucleotide (nt) piRNAs. H...
ORGANISM(S): Bombyx mori 
2015-07-09 | E-GEOD-69102 | biostudies-arrayexpress
TranscriptomicsThe MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs
Piwi-interacting RNAs (piRNAs) guide Piwi Argonautes to suppress transposon activity in animal gonads. Known piRNA populations are extremely complex, with millions of individual sequences present in a single organism. Despite this complexity, specific Piwi proteins incorporate piRNAs with distinct n...
ORGANISM(S): Bombyx mori 
2014-07-01 | E-GEOD-55451 | biostudies-arrayexpress
TranscriptomicsLiver Pharmacology and Xenobiotic Response Repertoire
A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology. We have used a ...
ORGANISM(S): Rattus norvegicus 
2008-03-28 | E-GEOD-8858 | biostudies-arrayexpress
TranscriptomicsPIWI slicing and EXD1 drive biogenesis of nuclear piRNAs from cytosolic targets of the mouse piRNA pathway
PIWI-interacting RNAs (piRNAs) guide PIWI proteins to suppress transposable elements in animal gonads. Here we demonstrate that in the mouse embryonic male germline, endonucleolytic cleavage (slicing) of a transcript by cytosolic MILI acts as a trigger to initiate its further 5??3? processing into n...
ORGANISM(S): Mus musculus 
2015-12-04 | E-GEOD-74423 | biostudies-arrayexpress
TranscriptomicsTudor domain containing 12 (TDRD12) is essential for secondary piRNA biogenesis in mice
Piwi-interacting RNAs (piRNAs) are gonad-specific small RNAs that provide defence against transposable genetic elements called transposons. Our knowledge of piRNA biogenesis is sketchy, partly due to an incomplete inventory of the factors involved. Here, we identify Tudor domain-containing 12 (TDRD1...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-50544 | biostudies-arrayexpress
TranscriptomicsDevelopment of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection
Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understand Mechanisms of Chemical Toxicity and Action These data support the publication titled "Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understa...
ORGANISM(S): Rattus norvegicus 
2005-05-31 | E-GEOD-2409 | biostudies-arrayexpress
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