Sort   by:  
 Page size 
TranscriptomicsTranscriptional Profiling is Superior to Procalcitonin to Discriminate Bacterial vs. Viral Lower Respiratory Tract Infections in Hospitalized Adults
Background: Distinguishing between bacterial and viral lower respiratory tract infections (LRTI) in hospitalized patients remains challenging. Transcriptional profiling is a promising tool for improving diagnosis in LRTI. Methods: We performed whole blood transcriptional analysis in a cohort of ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-60244 | biostudies-arrayexpress
TranscriptomicsBlood Leukocyte Microarrays to Diagnose Systemic Onset Juvenile Idiopathic Arthritis and Follow IL-1 blocade
Systemic onset Juvenile Idiopathic Arthritis (SoJIA) represents up to 20% of Juvenile Idiopathic Arthritis (JIA). We have previously reported that this disease is Interleukin 1 (IL1)-mediated, and that IL-1 blockade results in clinical remission in the majority of patients. The diagnosis of SoJIA, h...
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-8650 | biostudies-arrayexpress
TranscriptomicsTrivalent Inactivated Influenza Vaccine (TIV) and Live Attenuated Influenza Vaccine (LAIV) Induce Different B cell and Transcriptional Responses in Children
LAIV and TIV are effective for prevention of influenza infection in children, but the mechanisms associated with protection are still not well defined. We analyzed the differences in B cell responses and transcriptional profiles. Compared to baseline, LAIV elicited a significant increase in naM-CM-/...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-52005 | biostudies-arrayexpress
TranscriptomicsIFNa and IL4 DCs stimulated with microbial components for 6hr
While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DC...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44719 | biostudies-arrayexpress
TranscriptomicsIFNa DCs and IL4 DCs exposed to H1N1, heat killed S. aureus, or heat killed S. enterica (HKSE) for 1h, 2h, 6h, 12h, or 24h
While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DC...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44720 | biostudies-arrayexpress
TranscriptomicsIL4 DCs and monocytes stimulated by 13 human vaccines and LPS for 6hr
While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DC...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44721 | biostudies-arrayexpress
TranscriptomicsTranscriptional specialization of human dendritic cell subsets in response to microbial vaccines
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44722 | biostudies-arrayexpress
Sort   by:  
 Page size