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B cell antigen receptor (BCR) signaling is initiated by protein kinases and limited by counteracting phosphatases that currently are less well studied in their regulation of BCR signaling. We here used the B cell line Ramos to identify and quantify human B cell signaling components. Specifically, a ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD024037 | Pride
B cell antigen receptor (BCR) signaling is initiated by protein kinases and limited by counteracting phosphatases that currently are less well studied in their regulation of BCR signaling. We here used the B cell line Ramos to identify and quantify human B cell signaling components. Specifically, a ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD024038 | Pride
ChIP-chip experiments with NimbleGen whole-genome tiling arrays to compare Su(Hw), dCTCF, BEAF, and CP190 localization on DNA in Kc and Mbn2 cells revealed that BEAF is a third subclass of CP190-containing insulators. The DNA binding proteins, Su(Hw), dCTCF, and BEAF show unique distribution patter...
ORGANISM(S): Drosophila melanogaster 
CD20 is a B cell-specific four-helix transmembrane protein and a prominent target of successful therapeutic anti-CD20 antibodies such as rituximab (RTX) and GA101. We have recently described that CD20 is localized within a membrane nanocluster harboring the IgD class B cell antigen receptor (IgD-BCR...
ORGANISM(S): Homo sapiens (Human) 
2026-04-17 | PXD063667 | Pride
We mapped the localization of insulator proteins in Drosophila S2 cells in the presence or absence of 12mM of 3AB. We found that inhibition of PARylation affects DNA binding of insulator proteins only at a small subsets of genomic sites. Examination of genomic occupancy for insulator proteins in S2 ...
ORGANISM(S): Drosophila melanogaster 
Comparison of gene expression between Kc and Mbn2 cell lines derived from Drosophila melanogaster. Microarray analysis was performed with two biological replicates for each cell line. Each array contains 15,634 Drosophila genes in duplicate with 12, 60 mer probes per gene.
ORGANISM(S): Drosophila melanogaster 
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