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ProteomicsA novel Traditional Chinese Medicine, Ramulus Mori (Sangzhi) alkaloids ameliorates glucose metabolism accompanied by the modulation of gut microbiota and ileal inflammatory damage in type 2 diabetic KKAy mice
The novel Traditional Chinese Medicine Ramulus Mori (Sangzhi) alkaloid tablets (SZ-A) are approved by The China National Medical Products Administration for the treatment of type 2 diabetes mellitus (T2DM). However, the extensive pharmacological characteristics and the underlying mechanism are unkno...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024241 | Pride
Ramulus mori (sangzhi) alkaloids  type 2 diabetes  gut microbiome  ileal damage  inflammation 
TranscriptomicsRamulus Mori (Sangzhi) Alkaloids Attenuate Diet-Induced Obesity by Promoting White Adipose Browning and Enhancing Brown Fat Thermogenesis
Obesity is a chronic metabolic disorder characterized by excessive adipose accumulation and is closely associated with type 2 diabetes mellitus (T2DM), cardiovascular diseases, and metabolic dysfunction associated steatotic liver disease. Enhancing adipose thermogenic capacity has emerged as a promi...
ORGANISM(S): Mus musculus 
2025-12-04 | GSE312093 | GEO
GenomicsRamulus Mori (Sangzhi) Alkaloids Attenuate Diet-Induced Obesity by Promoting White Adipose Browning and Enhancing Brown Fat Thermogenesis
Ramulus Mori (Sangzhi) Alkaloids Attenuate Diet-Induced Obesity by Promoting White Adipose Browning and Enhancing Brown Fat Thermogenesis
PRJNA1372171 | ENA
UnknownRamulus Mori (Sangzhi) Alkaloids Ameliorate Obesity-Linked Adipose Tissue Metabolism and Inflammation in Mice.
Not available
S-EPMC9739644 | biostudies-literature
UnknownRamulus Mori (Sangzhi) Alkaloids Alleviate High-Fat Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice.
Not available
S-EPMC9137915 | biostudies-literature
UnknownPharmacokinetics and tissue distribution of Ramulus Mori (Sangzhi) alkaloids in rats and its effects on liver enzyme activity.
Not available
S-EPMC9981942 | biostudies-literature
UnknownRamulus mori (Sangzhi) alkaloids regulates gut microbiota disorder and its metabolism profiles in obese mice induced by a high-fat diet.
Not available
S-EPMC10102453 | biostudies-literature
UnknownRamulus Mori (Sangzhi) Alkaloids (SZ-A) Ameliorate Glucose Metabolism Accompanied by the Modulation of Gut Microbiota and Ileal Inflammatory Damage in Type 2 Diabetic KKAy Mice.
Not available
S-EPMC8082153 | biostudies-literature
TranscriptomicsRNA Sequencing Analysis of the epididymal adipose tissue from Normal Chow, HFD Control and SZ-A-treated HFD mice
Ramulus Mori (Sangzhi) alkaloids (SZ-A) improves lipid metabolism and adipose tissue inflammation in HFD-induced obese mice.This study compares transcriptome profiling (RNA-seq) in the epididymal adipose tissue of normal chow, high-fat diet (HFD) control and SZ-A-treated HFD mice to verify the regul...
ORGANISM(S): Mus musculus 
2022-11-20 | GSE214618 | GEO
TranscriptomicsRNA Sequencing Analysis of liver from Normal Chow, HFD Control and SZ-A-treated HFD mice
Ramulus Mori (Sangzhi) alkaloids (SZ-A) alleviates nonalcoholic fatty liver disease in mice. This study compares transcriptome profiling (RNA-seq) in the liver of normal chow, high-fat diet (HFD) control and SZ-A-treated HFD mice to verify the regulatory mechanisms of SZ-A. These results demonstrate...
ORGANISM(S): Mus musculus 
2022-03-23 | GSE199105 | GEO
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