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MetabolomicsVirus-induced codon-specific reprogramming to favor viral RNA translation
Recent evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express their genomes at high levels despite an enrichment in rare codons remains a puzzling question. Using ribosome footprinting, here we analysed ...
2025-06-16 | MTBLS2443 | MetaboLights
MetabolomicsP53 dependent hypusination of eIF5A affect mitochondrial translation and senescence immune surveillance
Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Her...
2024-08-14 | MTBLS10690 | MetaboLights
ProteomicsCGG repeat RNA binding protein capture identifies SRSF protein kinase 1 as a modulator of RAN translation and suppressor of repeat toxicity
Transcribed CGG repeat expansions cause the neurodegenerative disorder Fragile X-associated tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA-binding proteins (RBPs) into nuclear foci and undergo repeat-associated non-AUG (RAN) translation into toxic peptides in the cytoplasm. To identif...
ORGANISM(S): Homo sapiens (Human) 
2021-09-28 | PXD027000 | Pride
Ran translation Repeat rna 
GenomicsMechanistic insights into RAN translation within the Huntingtin coding sequence
Mechanistic insights into RAN translation within the Huntingtin coding sequence
PRJNA1463861 | ENA
TranscriptomicsMechanistic insights into RAN translation within the Huntingtin coding sequence
Nucleotide repeat expansions support the production of toxic peptides from putatively non-coding regions of the human genome in the absence of an AUG initiation codon. This process, known as repeat-associated non-AUG (RAN) translation, was originally described at CAG repeat expansions with products ...
ORGANISM(S): Homo sapiens 
2026-05-13 | GSE330454 | GEO
GenomicsSynergy between CGG Repeat RNA and RAN translation drives FXTAS pathogenesis through Protein Kinase R
Synergy between CGG Repeat RNA and RAN translation drives FXTAS pathogenesis through Protein Kinase R
PRJNA1529061 | ENA
UnknownRAN Translation in Huntington Disease.
Not available
S-EPMC4684947 | biostudies-literature
UnknownMetformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice.
Not available
S-EPMC7414156 | biostudies-literature
TranscriptomicsTranslation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation
Macrophage activation by bacterial lipopolysaccharides (LPS) is induced through Toll-like receptor 4 (TLR4). The synthesis and activity of TLR4 downstream signalling molecules modulates the expression of pro- and anti-inflammatory cytokines. To address the impact of post-transcriptional regulation o...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-48463 | biostudies-arrayexpress
TranscriptomicsSynergy between CGG Repeat RNA and RAN translation drives FXTAS pathogenesis through Protein Kinase R
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by transcribed CGG repeat expansions in the 5′ untranslated region of FMR1. Both CGG repeat RNA and repeat-associated non-AUG (RAN) translation of the polyglycine-containing protein FMRpolyG are imp...
ORGANISM(S): Mus musculus 
2026-09-16 | GSE347172 | GEO
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