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TranscriptomicsGenomic characterization implicates iAMP21 as a primary genetic event in childhood B-cell precursor acute lymphoblastic leukaemia
Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct subgroup of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) shown to have a dismal outcome on standard therapy. For improved diagnosis and prognosis of these patients, the initiating genetic events need to ...
ORGANISM(S): Homo sapiens 
2012-03-02 | E-GEOD-26192 | biostudies-arrayexpress
TranscriptomicsDeregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in BCP-ALL
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia We report two novel, cryptic chromosomal abnormalities in precursor B-cell acute lymphoblastic leukemia (BCP-ALL): a translocation, either t(X;14)(p22;q32)...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17165 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of relapsed Acute Lymphoblastic Leukaemia in children
Identification of de novo copy number abnormalities arising in relapsed paediatric ALL in matched presentation and relapse samples. We identified deletions of BACH2, (BTB and CNC homology 1, basic leucine zipper transcription factor 2) at relapse. To study the role of Bach2 in pre-B ALL in a genetic...
ORGANISM(S): Homo sapiens 
2013-12-21 | E-GEOD-43060 | biostudies-arrayexpress
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