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TranscriptomicsERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation
To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were decreased in these mice. To define Erg downstream target genes in hematopoietic stem cells, we sorted...
ORGANISM(S): Mus musculus 
2015-09-21 | E-GEOD-69873 | biostudies-arrayexpress
GenomicsTemporal mapping of C/EBPα and –β binding during liver regeneration
Temporal mapping of C/EBPα and –β binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries. Timeseries ChIP-seq of transcription factors C/EBPα and –β, and Pol II in time points 0, 3, 8, 16, 24, 36, 48, 168 hours after pa...
ORGANISM(S): Mus musculus 
2013-01-24 | E-GEOD-42321 | biostudies-arrayexpress
TranscriptomicsThe Hematopoietic System - Myeloid arm
We used microarray to create a normal cell landscape for the myeloid arm of the hematopoietic system. Mononuclear bone marrow cells from heathly donors were enriched for 34+ and hematopoietic stem and progenitor cells were sorted by FACS.
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-42519 | biostudies-arrayexpress
TranscriptomicsLoss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis [Agilent]
DNA methylation is tightly regulated throughout mammalian development and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protect...
ORGANISM(S): Mus musculus 
2015-04-30 | E-GEOD-68415 | biostudies-arrayexpress
TranscriptomicsIn Vitro Transformation of Primary Human CD34+ Cells by AML Fusion Oncogenes: Early Gene Expression Profiling Reveals Possible Drug Target in AML
Different fusion oncogenes in acute myeloid leukemia (AML) have distinct clinical and laboratory features suggesting different modes of malignant transformation. Here we compare the in vitro effects of representatives of major groups of AML fusion oncogenes on primary human CD34+ cells. For the 3 d ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-57194 | biostudies-arrayexpress
GenomicsDNA_Methylation_450K
BLUEPRINT DNA methylation profiles of monocytes, neutrophils and T cells from healthy donors
EGAD00010000850 | EGA
ProteomicsQuantitative Single-Cell Proteomics as a Tool to Characterize Cellular Hierarchies
Large-scale single-cell analyses are of fundamental importance in order to capture biological heterogeneity within complex cell systems, but have largely been limited to RNA-based technologies. Here we present a comprehensive benchmarked experimental and computational workflow, which establishes glo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-21 | MSV000090570 | MassIVE
GenomicsBLUEPRINT EpiVar 450K DNA methylation profiles of naive CD4+ T-cells, monocytes & neutrophils
BLUEPRINT EpiVar 450K DNA methylation profiles of naive CD4+ T-cells, > monocytes & neutrophils
EGAS00001001456 | EGA
TranscriptomicsA genome-wide map of transcription start sites specific for acute promyelocytic leukemia reveals deregulation of full-length transcripts
Transcription start sites are the focal points of transcriptional regulation, where information from regulatory elements is integrated to stabilize initiation of transcription. In humans, most genes have more than one transcription start site, and these often exhibit different tissue specificity, se...
ORGANISM(S): Homo sapiens 
2014-01-31 | E-GEOD-46561 | biostudies-arrayexpress
GenomicsC/EBPa is required for self-renewal, lineage priming and maintenance of epigenetic configurations in hematopoietic stem cells
Transcription factors are key regulators of hematopoieticstem cells (HSCs) and act through their ability to bind DNA andimpact on gene transcription. Their functions are interpreted inthe complex landscape of chromatin but current knowledge on howthis is achieved is very limited. C/EBPa is an import...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-43007 | biostudies-arrayexpress
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