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ModelsWang2009 - PI3K Ras Crosstalk
This model is from the article: PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk. Wang CC, Cirit M, Haugh JM Mol. Syst. Biol. 2009;5:246. 19225459 , A...
2024-09-02 | BIOMD0000000288 | BioModels
GenomicsPI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition
PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition
PRJNA1453925 | ENA
ModelsPadala2017- ERK, PI3K/Akt and Wnt signalling network (Ras mutated)
Padala2017- ERK, PI3K/Akt and Wnt signalling network (Ras mutated) Crosstalk model of the ERK, Wnt and Akt signalling pathways with Ras mutation. This model is described in the article: Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/?-catenin signaling network constituti...
2024-09-02 | BIOMD0000000654 | BioModels
GenomicsPI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [ChrRNAseq]
PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [ChrRNAseq]
PRJNA1430363 | ENA
GenomicsPI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [RNASeq]
PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [RNASeq]
PRJNA1430365 | ENA
TranscriptomicsPten loss and RAS/MAPK activation cooperate to promote EMT and prostate cancer metastasis initiated from stem/progenitor cells
PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies the end stage of human disease. To identify...
ORGANISM(S): Mus musculus 
2012-02-28 | E-GEOD-34839 | biostudies-arrayexpress
ProteomicsDissection of IL-2 and IL-15 signaling pathways
The aim of this study was to compare the signaling cascades initiated by the two closely related cytokines IL-2 and IL-15. Considering the relevance of protein tyrosine phosphorylation in signal transduction, in order to quantify changes in protein phosphorylation in response to IL-2 and IL-15, we c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080767 | MassIVE
OtherPI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition
Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious obstacle. We showed here that PI3K plays a major role in this resistance through upstream activation of wild-...
ORGANISM(S): Homo sapiens 
2026-04-28 | GSE328107 | GEO
TranscriptomicsCombined PI3K/mTOR and MEK Inhibition Provides Broad Anti-Tumor Activity in Faithful Murine Cancer Models
Anticancer drug development is an inefficient process, with potential therapeutics demonstrating a high attrition rate due to lack of efficacy in Phase II/III testing. In an effort to develop improved pre-clinical predictors of efficacy, we and others have turned to testing in genetically engineere...
ORGANISM(S): Mus musculus 
2012-08-21 | E-GEOD-35722 | biostudies-arrayexpress
GenomicsRas/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells
Ras/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells
PRJNA692213 | ENA
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