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TranscriptomicsRNAi knock-down of MKL1 in human megakaryocytes derived from cord blood or cytapheresis
Characterize the genes regulated by MKL1/SRF complex in human megakaryocytes (MKs) derived from cord blood or cytapheresis : Using a knock down approach by small interference of MKL1 in MK progenitors, we observed a decrease in the percentage of cells with actin polymerization after adhesion on vari...
ORGANISM(S): Homo sapiens 
2009-09-14 | E-TABM-640 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Mo7e cells transduced with control- or p210(BCR-ABL)-GFP viruses
The profiles of transcripts of Mo7e cells transduced with control- or p210(BCR-ABL)-GFP viruses were compared using microarrays to investigate
ORGANISM(S): Homo sapiens 
2007-10-31 | E-TABM-173 | biostudies-arrayexpress
TranscriptomicsDual role of EZH2 on megakaryocyte differentiation, analysis at different stages of maturation at day 9 of culture
EZH2, the enzymatic component of PRC2, has been identified as a key factor in hematopoiesis. EZH2 loss of function mutations have been found in myeloproliferative neoplasms, more particularly in myelofibrosis, but the precise function of EZH2 in megakaryopoiesis is not fully delineated. Here, we sho...
ORGANISM(S): Homo sapiens 
2021-11-02 | E-MTAB-8610 | biostudies-arrayexpress
UnknownEltrombopag, a potent stimulator of megakaryopoiesis.
Not available
S-EPMC5479610 | biostudies-literature
TranscriptomicsIGR_Raslova_IPS
FPD/AML is a constitutional disorder characterized by germline abnormalities in the hematopoietic transcription factor RUNX1, also called AML1. Mouse models have revealed the essential role of Runx1 during the first steps of hematopoiesis with an embryonic lethality and a complete absence of definit...
ORGANISM(S): Homo sapiens 
2014-01-19 | E-MTAB-1526 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of the effect of S78454, a pan histone deacetylase inhibitor, on megakaryopoiesis derived from human CD34+ cells
S78454 (Abexinostat, PCI-24781) is a pan histone deacetylase inhibitor (HDACi) that demonstrates efficacy in malignancy treatment. Like other HDACi, this drug induces a profound thrombocytopenia, whose mechanism is partially understood. We have tested its effect at doses reached in patients plasma o...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-MTAB-1180 | biostudies-arrayexpress
UnknownNew insights into regulation of αIIbβ3 integrin signaling by filamin A.
Not available
S-EPMC8924993 | biostudies-literature
UnknownDose-dependent effects of eltrombopag iron chelation on platelet formation.
Not available
S-EPMC12131944 | biostudies-literature
UnknownFirst description of revertant mosaicism in familial platelet disorder with predisposition to acute myelogenous leukemia: correlation with the clinical phenotype.
Not available
S-EPMC7556663 | biostudies-literature
UnknownA gain-of-function filamin A mutation in mouse platelets induces thrombus instability.
Not available
S-EPMC9826440 | biostudies-literature
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