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Gene expression of PreMegE cells from wild type mice was compared with those from conditional null mutants (Fog1 Floxed). Cre excision in mutant mice was induced with polyIC. PreMegE cells were isolated by FACS. Expression profiles of biological replicates were determined by hybridization to Affy...
ORGANISM(S): Mus musculus 
Oxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major unsolved problem. Consequently, predictive markers and a better understanding of resistance mechanisms are urgently needed. To investigate if the recently identified predictive miR-625-3p is functionally involved in oxPt resistance...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080762 | MassIVE
Purpose: Irinotecan (SN38) and oxaliplatin are chemotherapeutic agents used in the treatment of colorectal cancer. However, the frequent development of resistance to these drugs represents a considerable challenge in the clinic. Alus as retrotransposons comprise 11% of the human genome. Genomic toxi...
ORGANISM(S): Homo sapiens 
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