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MetabolomicsUntargeted gas chromatography–mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat
Polycystic kidney disease (PKD) encompasses a spectrum of inherited disorders that lead to end-stage renal disease (ESRD). There is no cure for PKD and current treatment options are limited to renal replacement therapy and transplantation. A better understanding of the pathobiology of PKD is needed ...
2023-01-26 | MTBLS748 | MetaboLights
MetabolomicsTissue, urine and serum NMR metabolomics dataset from a 5/6 nephrectomy rat model of chronic kidney disease

Serum, urine and tissue from a rat model of chronic kidney disease (CKD) were analysed using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics methods, and compared with samples from sham operated rats. Both urine and serum were sampled at multiple timepoints, and the results have ...

2020-11-16 | MTBLS2052 | MetaboLights
MetabolomicsMetabolomics dataset of PPAR-pan treated rat liver (eicosanoid assay)

This article contains mass spectrometry (MS) data investigating small molecule changes as an effect of a triple peroxisome proliferator-activated receptor (PPAR-pan) agonist GW625019 in the liver as described in the manuscript “PPAR-pan Activation Induces Hepatic Oxidative Stress and Lipidomic Re...

2016-05-13 | MTBLS278 | MetaboLights
MetabolomicsMetabolomics dataset of PPAR-pan treated rat liver (acyl-carnitine and aqueous metabolite assays)

This article contains mass spectrometry (MS) data investigating small molecule changes as an effect of a triple peroxisome proliferator-activated receptor (PPAR-pan) agonist GW625019 in the liver as described in the manuscript “PPAR-pan Activation Induces Hepatic Oxidative Stress and Lipidomic Re...

2016-05-13 | MTBLS303 | MetaboLights
MetabolomicsDietary germ oil-derived phytosterols ameliorate hyperlipidemia by suppressing bile salt hydrolase-producing gut microbiota to enrich taurohyodeoxycholic acid_Bile acid profile in rat liver tissue

Dyslipidemia is a major cardiovascular risk factor. While dietary phytosterols are known to lower cholesterol, the mechanisms involving the gut-liver axis are not fully understood. By integrating human clinical trials and mechanistic animal models, we demonstrate that phytosterols improve lipid p...

2026-03-17 | MTBLS13655 | MetaboLights
MetabolomicsEffects of Centella asiatica extract on antioxidant status and liver metabolome of rotenone-treated rats using GC-MS
The standardized extract of Centella asiatica (ECa233) contains >80% triterpenoids with a ratio of madecassoside to asiaticoside of 1.5(±0.5):1. Hepatoprotective effect of ECa233 has not yet been reported. The aim of this study was to examine the effect of ECa233 on liver metabolome of rotenone-trea...
2018-10-11 | MTBLS522 | MetaboLights
MetabolomicsAssessing metabolic changes to maternal rat liver tissue during and post-pregnancy (part II)
Not available
ORGANISM(S): Mus musculus 
ST000510 | MetabolomicsWorkbench
MetabolomicsMacrosteatosis Cause Graft Failure Via Proliferative Arrest in Rats after Liver Transplantation
We created a rat model with macrosteatosis (MaS) liver via methionine-cholinedeficient food (MCD) diet and transplanted the MaS liver into normal rats, then the rats without any MaS will be set as control. In the whole process of surgeries, we procured the liver tissue samples in different time poin...
2023-11-20 | MTBLS4163 | MetaboLights
MetabolomicsRevealing Hidden Variables in DESI-based Spatial Metabolomics: Solvent Composition and Tissue Type as Critical Drivers
In the development of a desorption electrospray ionization (DESI) workflow for spatial metabolomics, we investigated the impact of two commonly used solvent systems, 90% acetonitrile (ACN) and 90% methanol (MeOH), on the spatial metabolomic profiling of multiple murine tissues. The performance of bo...
2026-09-11 | MTBLS14771 | MetaboLights
MetabolomicsAntidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique p...
2019-05-24 | MTBLS836 | MetaboLights
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